Results 161 to 170 of about 32,237 (256)

United States Experience With Terlipressin in Hepatorenal Syndrome: Response, Mortality, and Transplant Outcomes - Results From the HRS Harmony Consortium. [PDF]

Clin Gastroenterol Hepatol
Patidar KR, Cullaro G, Orman ES, Teixeira JP, Neyra JA, Robinson JE, Kapoor A, Simonetto DA, Gonzalez SA, Asrani SK, Vargas HE, Rajan A, Fricker Z, Weinberg E, Velez JC, Belcher JM, Wadei H, Fortune B, Frederick RT, Mehkri O, Dolan B, Pickett C, Skvarce J, Sachar S, Lindenmeyer C, Ouyang T, Ufere N, Li X, Lopes L, St Hillien S, Whittaker S, Kusztos V, Vellutini N, Vissa A, Walker OC, Fischbach C, Boike J, Subocz M, Aghayeva S, Skipper G, Marin LM, Singh R, Alhayani I, Zakour G, Haddad W, Mejia P, Allegretti AS, HRS-HARMONY Research Collaboration.   +47 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A GIS-based fermatean fuzzy MCDM approach for identifying the optimal sites for solar power plant installation in Kermanshah Province. [PDF]

Sci Rep
Zandi I, Pahlavani P, Lotfata A, Ata B.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study. [PDF]

Cureus
Ayad S, Pergolizzi CS, Raffa RB, Noor R, Pergolizzi JV.   +4 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects. [PDF]

Mol Oncol
Sun M, Wang J, Wan S.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes. [PDF]

Cell
Xing J, Tan M, Leshchiner D, Sun M, Abdelgied M, Huang L, Paithankar S, Uhl K, Shankar R, Lisabeth E, Aleiwi B, Jager T, Lawson C, Chen R, Giletto M, Girgis R, Neubig RR, So S, Ellsworth E, Li X, Chua MS, Zhou J, Chen B.   +22 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source