Results 91 to 100 of about 13,074 (260)
Academic Rankings — Where Are They Heading?
Вопросы образования, 2017 The global ranking system is in a state of violent transformation. We can already see the emerging contours of a new ranking system with the four distinguished elements: regional systems, customer-centered systems, multi-league systems, discipline-based ...
Waldemar Siwinski
doaj +1 more source
Complementing Büchi Automata with Ranker
, 2022 AbstractWe present the toolRankerfor complementing Büchi automata (BAs).Rankerbuilds on our previous optimizations of rank-based BA complementation and pushes them even further using numerous heuristics to produce even smaller automata. Moreover, it contains novel optimizations of specialized constructions for complementing (i) inherently weak automata
Vojtěch Havlena +2 more
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
List rankings and on-line list rankings of graphs [PDF]
, 2014 A $k$-ranking of a graph $G$ is a labeling of its vertices from $\{1,\ldots,k\}$ such that any nontrivial path whose endpoints have the same label contains a larger label.
McDonald, Daniel C.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
DiaRAG: intelligent question-answering system for the diabetes domain
工程科学学报To address the dual requirements of efficiency and professionalism in diabetes-related intelligent question-answering, this study presents DiaRAG, an innovative system that synergistically integrates knowledge graphs with retrieval-augmented generation ...
Tao YANG +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Frontiers in Neuroscience, 2016 Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9 and SLC6A4) in an ...
John Alexander +28 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source