Results 91 to 100 of about 3,068 (277)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Metric-guided Distillation: Distilling Knowledge from the Metric to Ranker and Retriever for Generative Commonsense Reasoning

, 2022
Commonsense generation aims to generate a realistic sentence describing a daily scene under the given concepts, which is very challenging, since it requires models to have relational reasoning and compositional generalization capabilities.
Jiao, Jian, He, Xingwei, Zhou, Bartuer, Gong, Yeyun, Cheng, Biao, Qi, Weizhen, Zhang, Hang, Jin, A-Long, Duan, Nan, Yiu, SM   +9 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

DiaRAG: intelligent question-answering system for the diabetes domain

工程科学学报
To address the dual requirements of efficiency and professionalism in diabetes-related intelligent question-answering, this study presents DiaRAG, an innovative system that synergistically integrates knowledge graphs with retrieval-augmented generation ...
Tao YANG, Chunping OUYANG, Ying YU, Yaping WAN   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Targeted re-sequencing approach of candidate genes implicates rare potentially functional variants in Tourette Syndrome etiology

Frontiers in Neuroscience, 2016
Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9 and SLC6A4) in an ...
John Alexander, Hera Potamianou, Jinchuan Xing, Jinchuan Xing, Li Deng, Li Deng, Iordanis Karagiannidis, Fotis Tsetsos, Petros Drineas, Tárnok Zsanett, Renata Rizzo, Tomasz Wolanczyk, Luca Farkas, Peter Nagy, Urszula Szymanska, Christos Androutsos, Vaia Tsironi, Anastasia Koumoula, Csaba Barta, Paul Sandor, Cathy L. Barr, Cathy L. Barr, Jay Tischfield, Jay Tischfield, Peristera Paschou, Gary Adam Heiman, Gary Adam Heiman, Marianthi Georgitsi, Marianthi Georgitsi   +28 more
doaj   +1 more source

Multi-dueling bandits and their application to online ranker evaluation [PDF]

, 2016
Online ranker evaluation focuses on the challenge of efficiently determining, from implicit user feedback, which ranker out of a finite set of rankers is the best.
Seldin, Y, Yevgeny Seldin, Brost, Brian, Lioma, C, Seldin, Yevgeny, Brian Brost, Brost, B, Cox, IJ, Ingemar J. Cox, Lioma, Christina, Christina Lioma, Cox, Ingemar Johansson   +11 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

R3: Reinforced Ranker-Reader for open-domain Question Answering [PDF]

, 2018
In recent years researchers have achieved considerable success applying neural network methods to question answering (QA). These approaches have achieved state of the art results in simplified closed-domain settings such as the SQuAD (Rajpurkar et al ...
GUO, Xiaoxiao, KLINGER, Tim, YU, Mo, CHANG, Shiyu, WANG, Shuohang, WANG, Zhiguo, JIANG, Jing, Tesauro, Gerry, TESAURO, Gerald, ZHANG, Wei, ZHOU, Bowen   +10 more
core   +1 more source