Results 121 to 130 of about 13,396 (303)
Generating Concise and Readable Summaries of XML Documents
, 2009 XML has become the de-facto standard for data representation and exchange, resulting in large scale repositories and warehouses of XML data. In order for users to understand and explore these large collections, a summarized, bird's eye view of the ...
Ifrim, Georgiana +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Long Document Re-ranking with Modular Re-ranker [PDF]
, 2022 Luyu Gao, Jamie Callan
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Comparative Analysis of Selected Filtered Feature Rankers Evaluation of Cyber Attacks Detection
, 2021 Olasehinde Olayemi O. +2 more
openalex +1 more source
Hierarchical Re-ranker Retriever (HRR)
Retrieving the right level of context for a given query is a perennial challenge in information retrieval - too large a chunk dilutes semantic specificity, while chunks that are too small lack broader context. This paper introduces the Hierarchical Re-ranker Retriever (HRR), a framework designed to achieve both fine-grained and high-level context ...
Singh, Ashish, Mohapatra, Priti
openaire +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Reproducibility of "A Light-Weight Strategy for Restraining Gender Biases in Neural Rankers"
, 2023 Alexander Haberl +2 more
openalex +1 more source