Results 131 to 140 of about 13,396 (303)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Multiple Filter-Based Rankers to Guide Hybrid Grasshopper Optimization Algorithm and Simulated Annealing for Feature Selection With High Dimensional Multi-Class Imbalanced Datasets [PDF]
, 2021 Abdulrauf Garba Sharifai +1 more
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
An Innovative Multiparametric Sensor Design for Detecting Microplastics and Heavy Metals
Elektronika ir ElektrotechnikaMicroplastics and heavy metals are materials that harm the environment and living organisms. Rapid detection enables their control or the identification of their sources. Conventional detection methods are expensive and require expert interpretation. The
Ekrem Kursad Dal +2 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Query-level Ranker Specialization
, 2017 Traditional Learning to Rank models optimize a single ranking function for all available queries. This assumes that all queries come from a homogenous source. Instead, it seems reasonable to assume that queries originate from heterogenous sources, where certain queries may require documents to be ranked differently.
Jagerman, R. +2 more
openaire +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Toward Automated Arabic Synonyms Extraction Using Arabic Lexical Substitution
IEEE AccessLexical Substitution (LS) replaces the target word or phrase with its synonym alternatives that are equivalent in meaning. Despite the richness of the Arabic language, Arabic LS received little attention as there are no benchmark evaluation datasets ...
Eman Naser-Karajah, Nabil Arman
doaj +1 more source