Results 61 to 70 of about 13,074 (260)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A Random Forest based predictor for medical data classification using feature ranking

Informatics in Medicine Unlocked, 2019
Medical data classification is considered to be a challenging task in the field of medical informatics. Although many works have been reported in the literature, there is still scope for improvement.
Md. Zahangir Alam, M. Saifur Rahman, M. Sohel Rahman   +2 more
doaj   +1 more source

Precise Request Tracing and Performance Debugging for Multi-tier Services of Black Boxes

, 2010
As more and more multi-tier services are developed from commercial components or heterogeneous middleware without the source code available, both developers and administrators need a precise request tracing tool to help understand and debug performance ...
Li, Yong, Meng, Dan, Sang, Bo, Wang, Lei, Zhan, Jianfeng, Zhang, Zhihong   +5 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Visual Semantic Re-ranker for Text Spotting [PDF]

, 2019
Many current state-of-the-art methods for text recognition are based on purely local information and ignore the semantic correlation between text and its surrounding visual context. In this paper, we propose a post-processing approach to improve the accuracy of text spotting by using the semantic relation between the text and the scene.
Sabir, Ahmed, Moreno-Noguer, Francesc, Padró, Lluís   +2 more
openaire   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Unbiased Learning to Rank with Unbiased Propensity Estimation

, 2018
Learning to rank with biased click data is a well-known challenge. A variety of methods has been explored to debias click data for learning to rank such as click models, result interleaving and, more recently, the unbiased learning-to-rank framework ...
Ai, Qingyao, Bi, Keping, Croft, W. Bruce, Guo, Jiafeng, Luo, Cheng   +4 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Human Evaluation of a German Surface Realisation Ranker [PDF]

Proceedings of the 12th Conference of the European Chapter of the Association for Computational Linguistics on - EACL '09, 2009
In this paper we present a human-based evaluation of surface realisation alternatives. We examine the relative rankings of naturally occurring corpus sentences and automatically generated strings chosen by statistical models (language model, log-linear model), as well as the naturalness of the strings chosen by the log-linear model. We also investigate
Aoife Cahill, Martin Forst
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source