Results 61 to 70 of about 3,068 (277)
Bioengineering, 2022 The eye is generally considered to be the most important sensory organ of humans. Diseases and other degenerative conditions of the eye are therefore of great concern as they affect the function of this vital organ. With proper early diagnosis by experts
Ahmed Al Marouf +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Bayesian Ranker Comparison Based on Historical User Interactions [PDF]
, 2020 We address the problem of how to safely compare rankers for information retrieval. In particular, we consider how to control the risks associated with switching from an existing production ranker to a new candidate ranker.
Shimon Whiteson +2 more
core
Answer Complex Questions: Path Ranker Is All You Need
, 2021 Currently, the most popular method for open-domain Question Answering (QA) adopts "Retriever and Reader"pipeline, where the retriever extracts a list of candidate documents from a large set of documents followed by a ranker to rank the most relevant ...
Lei Chen +21 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
R1-Ranker: Teaching LLM Rankers to Reason
Large language models (LLMs) have recently shown strong reasoning abilities in domains like mathematics, coding, and scientific problem-solving, yet their potential for ranking tasks, where prime examples include retrieval, recommender systems, and LLM routing, remains underexplored.
Feng, Tao +6 more
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Human Evaluation of a German Surface Realisation Ranker [PDF]
Proceedings of the 12th Conference of the European Chapter of the Association for Computational Linguistics on - EACL '09, 2009 In this paper we present a human-based evaluation of surface realisation alternatives. We examine the relative rankings of naturally occurring corpus sentences and automatically generated strings chosen by statistical models (language model, log-linear model), as well as the naturalness of the strings chosen by the log-linear model. We also investigate
Aoife Cahill, Martin Forst
openaire +2 more sources
Vasily Rozanov’s philosophy of low ranker
RUDN Journal of Philosophy, 2013 The article based on Vasily Rosanov’s writings of various periods makes the conclusion that his philosophy must be understand not as «pansexualism», but as the continuation of Russian thought with it’s traditions of heart love, pity, nonviolence ...
E S Grevtsova
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source