Results 41 to 50 of about 173,199 (249)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An approach to optimize transportation problemswith neutrosophic numbers based on a newranking function [PDF]

Archives of Control Sciences
A transportation problem (TP) is built on the framework of supply-demand and cost parameters which are uncertain in nature. Neutrosophic numbers are capable of handling incomplete information. This paper introduces a new solution approach to optimize TPs
Aakanksha Singh, Ritu Arora, Rajkumar Verma, Shalini Arora   +3 more
doaj   +1 more source

Rank metric codes and zeta functions [PDF]

Designs, Codes and Cryptography, 2017
We define the rank-metric zeta function of a code as a generating function of its normalized $q$-binomial moments. We show that, as in the Hamming case, the zeta function gives a generating function for the weight enumerators of rank-metric codes. We further prove a functional equation and derive an upper bound for the minimum distance in terms of the ...
I. Blanco-Chacón, E. Byrne, I. Duursma, J. Sheekey   +3 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ranking of Neutrosophic number based on values and ambiguities and its application to linear programming problem [PDF]

Neutrosophic Sets and Systems
The goal of this article is to establish a methodology for ordering of single-valued neutrosophic numbers (SVN-numbers) on the basis of values and ambiguities.
Manas Karak, Pramodh Bharati, Animesh Mahata, Subrata Paul, Santosh Biswas, Supriya Mukherjee, Said Broumi, Mahendra Rong, Banamali Roy   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Minkowski metrics in creating universal ranking algorithms [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2014
The paper presents a general procedure for creating the rankings of a set of objects, while the relation of preference based on any ranking function. The analysis was possible to use the ranking functions began by showing the fundamental drawbacks of ...
Andrzej Ameljańczyk
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Ranking Templates for Linear Loops [PDF]

Logical Methods in Computer Science, 2015
We present a new method for the constraint-based synthesis of termination arguments for linear loop programs based on linear ranking templates. Linear ranking templates are parameterized, well-founded relations such that an assignment to the parameters ...
Jan Leike, Matthias Heizmann
doaj   +1 more source