Results 181 to 190 of about 152,300 (264)

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

AI powered multi feature fusion framework for retrieving images using color, texture and shape descriptors. [PDF]

Sci Rep
Naveen K, Parvathi RMS.
europepmc   +1 more source

A Distributed Ranking Algorithm for the iTrust Information Search and Retrieval System

, 2013
Boyang Peng, L.E. Moser, P. M. Melliar‐Smith, Yung-Sung Chuang, I. Michel Lombera   +4 more
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

AI for evidence-based treatment recommendation in oncology: a blinded evaluation of large language models and agentic workflows. [PDF]

Front Artif Intell
Zhai G, Bar M, Cowan AJ, Rubinstein S, Shi Q, Zhang N, Xie E, Ma W.   +7 more
europepmc   +1 more source

Scalable Content-Based Ranking in P2P Information Retrieval

, 2008
Maroje Puh, Toan Luu, Ivana Podnar Žarko, Martin Rajman   +3 more
openalex   +2 more sources

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Automated Filtering and Visualization of Patient-Centered Data from Electronic Health Records in Emergency Care: A Scoping Review. [PDF]

J Multidiscip Healthc
Lenz J, Richter I, Meister S.
europepmc   +1 more source

Temporal ranking for fresh information retrieval [PDF]

, 2003
Nobuyoshi Sato, Minoru Uehara, Yoshifumi Sakai   +2 more
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source