Results 231 to 240 of about 152,300 (264)

Building a Safe and Transparent Workflow for Large Language Model (LLM)-Assisted Clinical Trials and Prediction Models: A Technical Report. [PDF]

Cureus
Frutuoso J.
europepmc   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review. [PDF]

Find ACL ACL
Xu Z, Ma H, Zhang G, Ding Y, Weng C, Peng Y.   +5 more
europepmc   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Ligand B-Factor Index: A Metric for Prioritizing Protein-Ligand Complexes in Docking. [PDF]

Mol Inform
Halip L, Neanu C, Avram S.
europepmc   +1 more source

Hybrid Algorithm For Page Ranking In Information Retrieval Systems

, 2016
Dushyant Singh Pallavi
openalex   +2 more sources

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

LINS: A general medical Q&A framework for enhancing the quality and credibility of LLM-generated responses. [PDF]

Nat Commun
Wang S, Zhao F, Bu D, Lu Y, Gong M, Liu H, Yang Z, Zeng X, Yuan Z, Wan B, Sun J, Wu Y, Zhao L, Wan X, Huang W, Wang T, Xu M, Luo J, Liu J, Zheng J, Zhang W, Zhang K, Zhang H, Wang S, Chen R, Zhao Y.   +25 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Grounded large language models for diagnostic prediction in real-world emergency department settings. [PDF]

JAMIA Open
Niset A, Melot I, Pireau M, Englebert A, Scius N, Flament J, El Hadwe S, Al Barajraji M, Thonon H, Barrit S.   +9 more
europepmc   +1 more source