Results 261 to 270 of about 142,624 (305)

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Empowering entity synonym set generation using flexible perceptual field and multi-layer contextual information. [PDF]

PLoS One
Huang S, Li D, Yu C, Chen J, Zhou Q, Liu S.   +5 more
europepmc   +1 more source

Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response

Advanced Science, EarlyView.
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li, Jiajun Tan, Chuqing Zhou, Siyi Zhou, Yuanli Ye, Xinzhu Li, Xinyu Shen, Tian Xie, Mengyue Wang, Jingwei Jiang, Yiping Zhao, Xiao Xiang, Yong Zhou, Jun Wu, Cheng‐Ming Chuong, Mingxing Lei   +15 more
wiley   +1 more source

Deep image features sensing with multilevel fusion for complex convolution neural networks & cross domain benchmarks. [PDF]

PLoS One
Shabir A, Ahmed KT, Mahmood A, Garay H, Prado González LE, Ashraf I.   +5 more
europepmc   +1 more source

Exosomal CCT6A Secreted by Cancer‐Associated Fibroblasts Interacts with β‐Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer

Advanced Science, EarlyView.
Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun, Tianqi Zhang, Xiaoyan Zhang, Yingxue Liu, Xu Wang, Xin Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Xiaoyu Wang, Wenfeng Wang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

Enhancing memory retrieval in generative agents through LLM-trained cross attention networks. [PDF]

Front Psychol
Hong C, He Q.
europepmc   +1 more source

Florigen and Florigen‐Like Genes Regulate Temperature‐Responsive Flowering in Tomato

Advanced Science, EarlyView.
This study uncovers that FLOWERING LOCUS T‐Like 2 (FTL2) and SINGLE‐FLOWER TRUSS (SFT) antagonistically regulate temperature‐responsive flowering in the tomato shoot apical meristem. High temperature induces floral repressor FTL2, which directly inhibits SFT to delay short‐day floral transition, while SFT reciprocally inhibits FTL2 to promote flowering.
Jia Song, Shiqi Zhao, Siyu Fang, Xiaotian Wang, Shuai Sun, Baohua Li, Ren Li, Lu Liu, Xia Cui   +8 more
wiley   +1 more source

Alpine Meadow Fractional Vegetation Cover Estimation Using UAV-Aided Sentinel-2 Imagery. [PDF]

Sensors (Basel)
Du K, Shao Y, Yao N, Yu H, Ma S, Mao X, Wang L, Wang J.   +7 more
europepmc   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Leveraging MDS2 and SBOM data for LLM-assisted vulnerability analysis of medical devices. [PDF]

Comput Struct Biotechnol J
Stein S, Pilgermann M, Weber S, Sedlmayr M.   +3 more
europepmc   +1 more source