Results 161 to 170 of about 116,082 (316)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Research output in New Zealand Economics Departments 2000-2006

, 2008
This paper considers the research productivity of New Zealand based economics departments over the period 2000 to 2006. It examines journal based research output across departments and individuals using six output measures.
Tressler, John, Anderson, David L.
core  

Rankings, creatividad y urbanismo

EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2008
La competencia entre ciudades constituye uno de los factores impulsores de procesos de renovación urbana y los rankings han devenido instrumentos de medida de la calidad de las ciudades.
JOAQUÍN SABATÉ, MANUEL TIRONI
doaj  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Rankings internacionales : metodología y posicionamiento de las universidades españolas

, 2015
Se analiza un grupo de rankings internacionales, los denominados League Tables (ARWU, THE, QS); un segundo grupo de rankings centrados en resultados de investigación (CWTS, HEEACT, SCIMAGO Institutions Ranking, URAP); y un tercer grupo de rankings ...
Sanz Casado, Elías, Casani Fernández de Navarrete, Fernando, Gómez Sancho, José María, Pandiella Dominique, Andrés, Pérez Esparrells, María del Carmen, Pastor Monsálvez, José Manuel   +5 more
core  

To rank or not to rank

Academic Medicine, 1985
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Unlocking the Secrets of College Rankings

The "Unlocking the Secrets of College Rankings'' course was designed to address the misunderstandings and over-emphasis on college rankings among high school students and their families. A lack of awareness of the limitations of these rankings could lead
Dou, Binbin
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source