Results 121 to 130 of about 236 (216)

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Ranking universitario en el Perú: plan piloto

open access: yes, 2006
El objetivo de este estudio era ofrecer un primer perfil académico de la universidad peruana bajo la hipótesis epistemológica que afirma que los hechos y procesos educacionales son cognoscibles a través del método científico que nos proporciona estrategias para lograr aproximaciones progresivas a la realidad, aprendiendo de nuestros errores.
openaire   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone   +5 more
wiley   +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

open access: yesHIV Medicine, EarlyView.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria   +555 more
wiley   +1 more source

Rankings universitarios: ¿Hacia una indeseable homogeneización de las universidades?

open access: yes, 2014
Capítulo 5. Ranking de producción científica de las universidades españolas y las instituciones de investigación.
Fernández de Lucio, Ignacio   +1 more
openaire   +1 more source

CH50 as a Clinically Useful Biomarker of Disease Activity and Antihistamine Resistance in Chronic Spontaneous Urticaria: An Observational Ambispective Single‐Center Study

open access: yesInternational Journal of Dermatology, EarlyView.
Personalized CSU care guided by CH50. ABSTRACT Background Chronic spontaneous urticaria (CSU) is frequently refractory to guideline‐based therapy, highlighting the need for predictive biomarkers. Dysregulation of the complement system has been implicated in CSU severity, but global complement activity has not been systematically evaluated.
Nidia Planella‐Fontanillas   +9 more
wiley   +1 more source

Long‐Term Serial Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia on Beta‐Blocker and Flecainide Therapy

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially life‐threatening arrhythmic disorder typically treated with beta‐blockers and, occasionally, with flecainide. Methods All patients underwent genetic testing, electrocardiogram, echocardiogram, and exercise testing.
Fernando Wangüemert‐Perez   +9 more
wiley   +1 more source

Delphi consensus: First‐line use of biologics and small molecules in hidradenitis suppurativa

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
This Delphi Consensus study identified upgrade criteria for the use of biologics and small molecules as first‐line therapy in hidradenitis suppurativa (HS). European HS experts evaluated 16 clinical scenarios, voting on eligibility for therapy escalation.
Georgios Nikolakis   +54 more
wiley   +1 more source

Variability in Vascular Access Device Use, Dwell Time and Failure: Insights From Routine Nursing Documentation in a Multicentre Cohort Study

open access: yesJournal of Clinical Nursing, EarlyView.
ABSTRACT Aims To describe and compare institutional patterns of vascular access device use, dwell time, and failure, and to explore their implications for nursing practice. Design Retrospective multicentre observational cohort study. Methods Routinely collected nursing records of vascular access device insertion and removal were analysed from seven ...
Ismael Fernández‐Fernández   +8 more
wiley   +1 more source

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