Results 211 to 220 of about 10,091 (248)

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez   +6 more
wiley   +1 more source

Limited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature

open access: yesClinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Clopidogrel is an antiplatelet agent widely utilized in cardiology. It is a prodrug activated in the liver by the cytochrome P450 isoform CYP2C19. Variability in the CYPC2C19 gene influences the activation and efficacy of clopidogrel. This is covered in guidelines from the Clinical Pharmacogenetics Implementation Consortium, the Dutch ...
Cinzia Dello Russo   +5 more
wiley   +1 more source

Microbiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing

open access: yesEuropean Journal of Haematology, Volume 116, Issue 5, Page 646-662, May 2026.
ABSTRACT The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.
Rafael Hernani   +22 more
wiley   +1 more source

Risk Profiles in Hospitalized Adults Based on Functional Capacity, Pressure Injury Risk, and Fall Risk: A Cluster and Multiple Correspondence Analysis

open access: yesJournal of Nursing Scholarship, Volume 58, Issue 3, May 2026.
ABSTRACT Background Patient safety is a global priority, as adverse events represent the 14th leading cause of morbidity and mortality worldwide. Among the most common complications in hospitalized adults are functional decline, pressure injuries, and falls, all of which increase hospital stays, healthcare costs, and mortality. Although these risks are
Irene Llagostera‐Reverter   +6 more
wiley   +1 more source

A Comprehensive Evaluation of Patient Satisfaction and Clinical Outcomes in Poly‐L‐Lactic Acid Treatments—A Randomized, Interventional, and Comparative Clinical Study

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Poly‐L‐lactic acid (PLLA) is widely used in aesthetic medicine due to its bio‐stimulatory properties. However, limited research has compared different PLLA formulations. Aim To evaluate the impact of PLLA formulation and injection depth (subcutaneous vs. supraperiosteal) using objective and subjective assessments.
Victor R. M. Munoz‐Lora   +10 more
wiley   +1 more source

A Systematic Review on Applications of Artificial Intelligence for Obesity Prevention

open access: yesObesity Reviews, Volume 27, Issue 5, May 2026.
ABSTRACT This systematic review examines the applications of artificial intelligence (AI) in preventing obesity, addressing a critical public health issue that affects a substantial portion of the population. With obesity rates rising alarmingly, particularly in the United States, this review synthesizes findings from 46 studies published between 2008 ...
Atefehsadat Haghighathoseini   +4 more
wiley   +1 more source

INSTALL baseline report [PDF]

open access: yes, 2012
González Monteagudo, José   +1 more
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