Results 81 to 90 of about 57,630 (294)
Engineering Applications of Computational Fluid MechanicsA novel development of Embedded Large Eddy Simulation (ELES) model was proposed for urban wind field simulations, incorporating the synthetic volume force method integrated with the Graphic Processing Unit (GPU) parallel computing.
Sunce Liao +7 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
3-D hybrid LES-RANS model for simulation of open-channel T-diversion flows
Water Science and Engineering, 2009 The study of flow diversions in open channels plays an important practical role in the design and management of open-channel networks for irrigation or drainage.
Jie Zhou, Cheng Zeng
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Journal of Ocean Engineering and Science, 2018 This paper presents our numerical study of the scale effects on a tip-rake propeller, the PPTC-II, based on the RANS simulations using software FLUENT 6.3.
Xiao-Qian Dong +3 more
doaj +1 more source
CFD modelling of wind turbine airfoil aerodynamics [PDF]
, 2008 This paper reports the first findings of an ongoing research programme on wind turbine computational aerodynamics at the University of Glasgow. Several modeling aspects of wind turbine airfoil aerodynamics based on the solution of the Reynoldsaveraged ...
Bonfiglioli, A. +4 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Energies, 2018 The performance of a transonic high pressure turbine is mainly influenced by the unsteady interactions associated with the passing blades. In this paper, the unsteady flow interactions in a transonic turbine have been numerically investigated using the ...
Muhammad Afzaal Asghar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source