Results 51 to 60 of about 78,270 (299)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Characterization of Asphalt Mixtures Produced with Coarse and Fine Recycled Asphalt Particles
Infrastructures, 2019 Utilizing recycled asphalt pavements (RAP) in pavement construction is known as a sustainable approach with significant economic and environmental benefits.
S. Saeed Saliani +3 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Free Swelling and Modulus of Elasticity of Compacted Black Cotton Soil Treated with Reclaimed Asphalt Pavement [PDF]
The Egyptian International Journal of Engineering Sciences and Technology, 2018 Black Cotton Soil (BCS), collected from Numan, in north-eastern region of Nigeriawas stabilized with Reclaimed Asphalt Pavement (RAP), collected from failed roadsurface, along Minna-Bida road in Niger state Nigeria. The BCS was replaced withRAP at 0%, 10%
M Alhassan, M Alhaji
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
HIGHER SCHOOL AND EMPLOYER ARE BUSINESS-EDUCATION PARTNERS
Модернизация, инновация, развитие, 2016 The competence approach in education means to focus on developing learning capabilities, self-determination, socialization and development of personality.
V. A. Pokhvoshchev +2 more
doaj
Experimental Investigation on Rheological Properties of Recycled Asphalt Pavement Mastics
Applied Rheology, 2015 Studies have shown that rheology of asphalt mastic plays an important role in pavement performance, specifically for the case of recycled asphalt pavement (RAP) mastics which contains mostly aged binder.
Mannan Umme Amina +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
DEVELOPMENT OF METHODS FOR STATE MANAGEMENT OF INVESTMENT PROCESSES, INVESTMENT OF RESOURCES
Модернизация, инновация, развитие, 2016 Owing to the accessibility to funds and resources required to support economics on the whole and most important branches in particular, the state is main investor to real sector of Russian economics. Unfortunately, this investment activity is implemented
A. Yu. Semenikhin
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source