Results 51 to 60 of about 45,601 (256)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Applied Sciences, 2017 Reclaimed asphalt pavement (RAP) has many advantages and is utilized to improve the high temperature properties of asphalt mixtures. Low temperature cracking is a predominant distress in asphalt pavements containing RAP materials. Thus, the evaluation of
Feipeng Xiao +3 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
International Journal of Technology, 2018 Black Cotton Soil (BCS) collected from Guyuk, Adamawa State- North-eastern Nigeria, was treated with 0 to 100% Reclaimed Asphalt Pavement (RAP) in 10% steps to evaluate the microstructure and strength of the compacted mixtures. The index property results
Mustapha Mohammed Alhaji, Musa Alhassan
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Impact of reclaimed asphalt pavement (RAP) on low-temperature properties of asphalt concrete
Roads and Bridges, 2019 Hot mix recycling is a practice which enables reusing materials from old asphalt pavements. Current Polish regulations allow usage of RAP only for binder and base courses, and its amount is limited.
Mariusz Jaczewski +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Experimental Investigation of Concrete Containing Recycled Asphalt Pavement (RAP) [PDF]
MATEC Web of ConferencesUsing recycled aggregate in concrete is an environmentally friendly solution that preserves the environment and the earth's natural resources. However, the suitability of recycled aggregate for use in structural concrete must be verified.
Ahmed Alwathaf +2 more
doaj +1 more source