Results 51 to 60 of about 43,833 (263)

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia are more frequent in advanced versus early Parkinson’s disease [PDF]

, 2021
Jirada Sringean, Ambra Stefani, Kathrin Marini, Melanie Bergmann, Mario Werkmann, Evi Holzknecht, Roberto De Marzi, Elisabeth Brandauer, Heinz Hackner, Atbin Djamshidian, Heike Stockner, Carles Gaig, Álex Iranzo, Joan Santamaría, Eduardo Tolosa, Klaus Seppi, Werner Poewe, Birgit Högl   +17 more
openalex   +1 more source

Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

Advanced Science, EarlyView.
This study introduces a behavioral paradigm for memory updating and reveals underlying hippocampal mechanisms. Replays of place cells predict future behavioral choices during behavior and show a bias toward high‐reward locations during non‐rapid eye movement (NREM) sleep, specifically within the memory updating process.
Jifu Tong, Yuanwei Xing, Yawen Zheng, Linshu Wang, Shan Shao, Jiao Wu, Longyu Ma, Shuting Liu, Naizheng Liu, Xuetao Qi, Ting Wang, Kun Cui, Shuang Cui, You Wan, Ming Yi   +14 more
wiley   +1 more source

Evolutionary Origin of Distinct NREM and REM Sleep

Frontiers in Psychology, 2020
Sleep is mandatory in most animals that have the nervous system and is universally observed in model organisms ranging from the nematodes, zebrafish, to mammals.
Risa Yamazaki, Hirofumi Toda, Paul-Antoine Libourel, Yu Hayashi, Yu Hayashi, Kaspar E. Vogt, Takeshi Sakurai, Takeshi Sakurai   +7 more
doaj   +1 more source

Bedtime to the brain: how infants’ sleep behaviours intertwine with non‐rapid eye movement sleep electroencephalography features [PDF]

, 2023
Sarah F. Schoch, Valeria Jaramillo, Andjela Markovic, Reto Huber, Malcolm Kohler, Oskar G. Jenni, Caroline Lustenberger, Salomé Kurth   +7 more
openalex   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder

npj Parkinson's Disease
Sleep disturbances, including rapid eye movement sleep behavior disorder (RBD), excessive daytime sleepiness, and insomnia, are common non-motor manifestations of Parkinson’s disease (PD).
Ying Chen, Wei-Ye Xie, Dong Xia, Mu-Tian Zhang, Yan-Rui Sun, Wen-Xiang Duan, Yun Shen, Fen Wang, Wei-Min Qu, Zhi-Li Huang, Chun-Feng Liu   +10 more
doaj   +1 more source