Results 51 to 60 of about 1,126,255 (302)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
BMC Health Services Research, 2020 Background Rapid Response Team (RRT) calls are clinical crises. Clinical and time pressures can hinder effective liaison between staff who call the RRT (‘users’) and those responding as part of the RRT (‘members’). Non-technical skills (NTS) training has
Richard Chalwin +4 more
doaj +1 more source
Rapid response teams: a diagnostic dilemma [PDF]
BMJ Quality & Safety, 2011 The implementation of rapid response teams (RRTs), also known as medical emergency teams, across the world has happened in parallel with the research to assess their effectiveness.1 The development of RRTs occurred due to observations that associated signs and symptoms are often present hours or days before clear clinical deterioration in the majority ...
Andre Carlos Kajdacsy-Balla, Amaral +1 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Rapid Response of an Academic Surgical Department to the COVID-19 Pandemic: Implications for Patients, Surgeons, and the Community. [PDF]
, 2020 BackgroundAs the coronavirus disease 2019 (COVID-19) pandemic continues to spread, swift actions and preparation are critical for ensuring the best outcomes for patients and providers.
Conte, Michael C +6 more
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
BMC Primary CareBackground Antibiotics are often prescribed without a C-Reactive Protein (CRP) level, an inflammatory marker used to guide treatment decisions, due to delays in obtaining laboratory results.
Matthew Atkins +8 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Communication Network Model for the Fast Reaction Team Program (Trc) “Saribattang” Children in Makassar City [PDF]
, 2017 The communication network helps provide the direction and policies of the Quick Response Team (TRC) Program "Saribattang" focus on addressing Social Welfare Problems (PMKS), especially street children, beggars, and sprawl.
Arianto, A. (Arianto) +2 more
core
Impact of a hospice rapid response service on preferred place of death, and costs [PDF]
, 2015 Background: Many people with a terminal illness would prefer to die at home. A new palliative rapid response service (RRS) provided by a large hospice provider in South East England was evaluated (2010) to provide evidence of impact on achieving ...
A Grady +32 more
core +1 more source