Results 51 to 60 of about 8,535,657 (256)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Performance evaluation of a point of care capillary blood test for C-reactive protein in community healthcare

open access: yesBMC Primary Care
Background Antibiotics are often prescribed without a C-Reactive Protein (CRP) level, an inflammatory marker used to guide treatment decisions, due to delays in obtaining laboratory results.
Matthew Atkins   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Modifying routine emergency medical team introductory training to a virtual storytelling (talanoa) format for Pacific island countries and areas

open access: yesWestern Pacific Surveillance and Response
This article describes the development of an online, remote and interactive emergency medical team (EMT) training series to engage current and prospective Pacific EMT team members during the COVID-19 pandemic. This was done incorporating talanoa sessions.
Anthony T Cook, Sean T Casey, Erin Noste
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

Pediatric Rapid Response Team Quality Improvement Initiative – Preliminary Findings [PDF]

open access: yes, 2021
Background: Rapid Response Teams are activated in non-critical care settings to provide or expedite access to escalated care before patient condition rapidly deteriorates.
McKnight, Heather   +2 more
core   +1 more source

Successful Implementation of a Rapid Response System in the Department of Internal Medicine [PDF]

open access: yesKorean Journal of Critical Care Medicine, 2014
Background: A rapid response system (RRS) aims to prevent unexpected patient death due to clinical errors and is becoming an essential part of intensive care.
Yeon Joo Lee   +11 more
doaj   +1 more source

Abstract 126: The Impact of Rapid Response Team Training on Team Dynamics and Provider Self-Confidence

open access: yes, 2011
Introduction Rapid Response Team (RRT) training is essential to early recognition and management of the critically ill patient. Using the Rapid Response Team Training curriculum (SimMedical and Lae..
Motola, Ivette   +4 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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