Results 101 to 110 of about 4,554,614 (308)

An at-home and electro-free COVID-19 rapid test based on colorimetric RT-LAMP

Journal of Infection in Developing Countries
Introduction: In the fight against virus-caused pandemics like COVID-19, diagnostic tests based on RT-qPCR are essential, but they are sometimes limited by their dependence on expensive, specialized equipment and skilled personnel.
Diem Hong Tran, Hau Thi Tran, Trang Nguyen Minh Pham, Le Minh Bui, Huong Thi Thu Phung   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Point-of-care N-terminal pro-brain natriuretic peptide testing in patients with heart failure: data from the DREAM study

Российский кардиологический журнал
Aim. To compare the blood levels of N-terminal pro-brain natriuretic peptide (NTproBNP), determined using a Russian semi-quantitative point-of-care test and quantitative laboratory tests, depending on the presence and severity of heart failure (HF) and ...
F. I. Belyalov, N. G. Lozhkina, O. A. Shtegman, R. N. Yagudina, O. V. Kankharey, I. V. Reshina, E. E. Sergeeva, D. F. Belyalov, N. S. Belyalova, Z. Kh. Zhilokov, A. V. Aleynikova, E. A. Medvedeva, A. A. Kharitonov   +12 more
doaj   +1 more source

Rapid chemical test for the identification of chromium-molybdenum steel [PDF]

This note describes a simple, rapid, qualitative test which can be applied to solutions of drilling or chips for the identification of chromium-molybdenum steel.
Redmond, John C
core   +1 more source

Microfluidic method for rapid turbidimetric detection of the DNA of Mycobacterium tuberculosis using loop-mediated isothermal amplification in capillary tubes [PDF]

, 2015
We describe a microfluidic method for rapid isothermal turbidimetric detection of the DNA of Mycobacterium tuberculosis. Loop-mediated isothermal amplification is accomplished in capillary tubes for amplifying DNA in less than 15 min, and sensitivity and
Gill, P., Rafati, A.
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An Improved Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method with Reduced Sample Volume

Biosensors
The four serotypes of dengue virus (DENV), types 1 to 4 (DENV-1 to DENV-4), exhibit approximately 60% identity in the encoded amino acid residues of viral proteins.
Warisara Sretapunya, Thitiya Buranachat, Montita Prasomthong, Rittichai Tantikorn, Areerat Sa-ngarsang, Sirirat Naemkhunthot, Laddawan Meephaendee, Pattara Wongjaroen, Chika Tanaka, Yoriko Shimadzu, Katsuya Ogata, Kunihiro Kaihatsu, Ryo Morita, Michinori Shirano, Juthamas Phadungsombat, Tadahiro Sasaki, Ritsuko Kubota-Koketsu, Yoshihiro Samune, Emi E. Nakayama, Tatsuo Shioda   +19 more
doaj   +1 more source

Is there any Association between Helicobacter Pylori Infection and Laryngeal Carcinoma [PDF]

Objective: To investigate the possible role of Helicobacter pylori as a cause of squamous cell carcinoma of larynx in a case-control study in an otolaryngology ward at an academic university.
خوشباطن, منوچهر, دوست محمدیان, ثریا, دوست محمدیان, نجمه, پیرزاده, اکبر   +3 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source