Results 51 to 60 of about 405,179 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gold nanoparticle-based lateral flow strips for rapid and sensitive detection of Virginiamycin M1

open access: yesFood and Agricultural Immunology, 2020
In this study, a sensitive and specific monoclonal antibody against VIR M1 was produced based on a new hapten. The antibody had a linear detection range of 3.77–65.51 ng/mL with an IC50 of 15.26 ng/mL and good specificity for VIR M1.
Xiaoxin Xu   +3 more
doaj   +1 more source

A Papertronic Sensing System for Rapid Visual Screening of Bacterial Electrogenicity

open access: yesJournal of Physics: Conference Series, 2019
Abstract In this work, we report a papertronic sensing system with the ability to achieve easy, rapid, and sensitive characterization of bacterial electrogenicity from a single drop of culture. Paper was used as a device substrate that inherently produces favorable conditions for easy, rapid, and sensitive and potentially high-throughput
Mehdi Tahernia   +2 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A Smartphone-Based Tool for Rapid, Portable, and Automated Wide-Field Retinal Imaging. [PDF]

open access: yes, 2018
Purpose:High-quality, wide-field retinal imaging is a valuable method for screening preventable, vision-threatening diseases of the retina. Smartphone-based retinal cameras hold promise for increasing access to retinal imaging, but variable image quality
Davila, Jose R   +15 more
core   +3 more sources

Asesmen Cepat Kerentanan Bangunan Sekolah Muhammadiyah Terhadap Gempabumi di Kecamatan Kasihan Bantul DIY

open access: yesSemesta Teknika, 2017
School buildings are included as buildings with risk category IV (SNI 1726: 2012) because it is potentially causing multiple casualties if earthquakes occur during school hours.
Restu Faizah, Muhammad Ibnu Syamsi
doaj  

Calibrating models in economic evaluation: a comparison of alternative measures of goodness of fit, parameter search strategies and convergence criteria.

open access: yes, 2011
BACKGROUND: The importance of assessing the accuracy of health economic decision models is widely recognized. Many applied decision models (implicitly) assume that the process of identifying relevant values for a model's input parameters is sufficient to
Karnon, Jonathan, Vanni, Tazio
core   +1 more source

Roar of the Thunder Dragon: the Bhutanese Audio-visual Industry and the Shaping and Representation of Contemporary Culture [PDF]

open access: yes, 2006
The Bhutanese audio-visual industry plays a critical and important role in the creation of cultural products, which are consumed by the masses. The industry's significant role in the preservation and promotion of culture is worthy of state support ...
Dendup, Tshewang
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

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