Results 31 to 40 of about 17,277 (262)

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

open access: yesAdvanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee   +8 more
wiley   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.

open access: yesPLoS ONE, 2014
PDK1 phosphorylates multiple substrates including Akt by PIP3-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α2-macroglobulin (α2M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by ...
Uma Kant Misra, Salvatore Vincent Pizzo
doaj   +1 more source

Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs

open access: yesAdvanced Science, EarlyView.
Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng   +6 more
wiley   +1 more source

Guidelines for the Anti‐Obesity Assays of Food Bioactives in Caenorhabditis elegans

open access: yesAgriFood: Journal of Agricultural Products for Food, EarlyView.
This Guideline uses Caenorhabditis elegans as a model organism to systematically explain and summarize the research strategies and experimental methods for the anti‐obesity effects of food bioactives. ABSTRACT The obesity has become a global public health problem and is closely related to a variety of chronic diseases.
Rui Lu
wiley   +1 more source

Status and Trends in the Eastern Imperial Eagle Population Between 1977 and 2018 in Slovakia

open access: yesПернатые хищники и их охрана, 2018
In Slovakia, two subpopulations of the Eastern Imperial Eagle (Aquila heliaca) – Western and Eastern Slovakian – are recognized with a distance between them of 200–300 km.
Jozef Chavko   +5 more
doaj  

CTNS mutations in publicly-available human cystinosis cell lines

open access: yesMolecular Genetics and Metabolism Reports, 2015
Patient samples play an important role in the study of inherited metabolic disorders. Open-access biorepositories distribute such samples. Unfortunately, not all clinically-characterized samples come with reliable genotype information.
Artem Zykovich   +3 more
doaj   +1 more source

Gaze‐Engineered 3D Augmented Reality

open access: yesAdvanced Intelligent Systems, EarlyView.
Augmented Reality (AR) systems serve as a critical interface bridging users with the metaverse. This study explores the application of human factors engineering in metaverse development, specifically investigating the integration of eye‐tracking technology to enhance AR display performance.
Naiqin Zhao   +3 more
wiley   +1 more source

Nest box use by American Kestrels and other cavity-nesting birds during the nonbreeding season

open access: yesAvian Conservation and Ecology, 2017
Nest boxes are posted to provide breeding sites for cavity-nesting birds but less is known about their function in the nonbreeding season, when nest boxes may become important roost sites.
Caitlin M. Davis   +2 more
doaj   +1 more source

A study of the correlation between the serum Latexin levels and the mTORC subunits Raptor and Rictor in the molecular pathogenesis of chronic lymphocytic leukemia

open access: yesMedicine Science, 2021
Hematopoietic stem cells (HSCs) ensure the lifelong production of blood cells throughout a lifetime. Latexin (Lxn) is thought to have a tumor suppressor role and endogenously down-regulate the number of HSCs via increased apoptosis.
Gokhan Pektas   +3 more
doaj   +1 more source

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