Results 61 to 70 of about 59,664 (266)

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

Nature Communications, 2016
The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a ...
KyeongJin Kim, Li Qiang, Matthew S. Hayden, David P. Sparling, Nicole H. Purcell, Utpal B. Pajvani   +5 more
doaj   +1 more source

Burrow use by Saharan striped polecat (Poecilictis libyca) in an agricultural area of central Tunisia

The Journal of Wildlife Management, EarlyView.
Saharan striped polecats in agricultural landscapes use many burrows (30–35 per season), facilitated by sandy soils. Burrow sharing is rare and mainly occurs between males and females during mating. Habitat use shifts seasonally, reflecting disturbance and soil conditions. Maintaining stable sandy habitats may be critical for persistence.
Firas Hayder, Zimkitha J. K. Madikiza, Emmanuel Do Linh San   +2 more
wiley   +1 more source

Northern bobwhites associated with native grass and shrubs have improved survival

The Journal of Wildlife Management, EarlyView.
Survival rates of adult northern bobwhites were improved by a combination of grazed native warm‐season grasses and well‐interspersed shrubs. Our study suggests that incorporating native warm‐season grass cattle forages into existing operations across the southeastern United States may be a viable working‐lands conservation strategy to create habitat ...
Douglas B. Mitchell, Patrick D. Keyser, David A. Buehler, James A. Martin, Cody M. Rhoden, Bridgett Costanzo   +5 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Advances in research on autophagy in the maintenance of insect–microbe symbiosis

New Plant Protection, EarlyView.
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang, Yuqiong Hao, Ke Chen, Hongbin Zhang, Xiansheng Xie, Feirong Ren   +5 more
wiley   +1 more source

Drought intensifies dominant competitor avoidance and risk‐dependent habitat selection in a large carnivore guild

Oikos, EarlyView.
Intraguild competition is a key force structuring predator communities, with dominant species impacting subordinate species' space use and access to resources. Climate change may intensify or reshape these processes, yet how climate conditions interact with dominance to influence predator space use and resource selection remains poorly understood.
Anna C. Nisi, Leigh West, Meghan Halabisky, Neil R. Jordan, Robynne Kotze, Andrew J. Loveridge, J. W. McNutt, John Neelo, Laura R. Prugh, Kasim Rafiq, Lara L. Sousa, Alan M. Wilson, Lukas Bierhoff, Briana Abrahms   +13 more
wiley   +1 more source

Different demographic drivers of recovery in two adjacent populations of a long‐lived bird of prey

Oikos, EarlyView.
Understanding the demographic mechanisms underlying population decline or recovery is critical for conservation and management, yet similar population trends may arise from very different underlying processes. Comparing populations of vulnerable species groups like long‐lived raptors in different environments can reveal how species respond to change ...
Carina Nebel, Toni Laaksonen, Torsten Stjernberg, Heikki Lokki, Michael Schaub   +4 more
wiley   +1 more source

RAPTOR gene polymorphism is independently correlated with urothelial cancer susceptibility compared with environmental toxin exposure

Urological Science, 2017
Introduction: There are many established environmental toxins that correlate with urothelial cancer. Genetic variations in phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway have also been reported to have association with ...
Hao Lun Luo, Po Huang Chiang, Nai Lun Lee, Po Hui Chiang   +3 more
doaj   +1 more source

Transforming a Poaching Hotspot: Embedded NGO Governance Between State and Community in Southern China

Public Administration and Development, EarlyView.
ABSTRACT This article examines how a local environmental NGO in southern China transformed Guantouling Hill, once a prominent poaching hotspot along the East Asian–Australasian Flyway, into a recognised model of community‐based biodiversity conservation.
Zheng Lin, Miao Chen
wiley   +1 more source

From traditional practice to unsustainable exploitation: Fruit overharvesting on the endangered relict palm Jubaea chilensis

PLANTS, PEOPLE, PLANET, EarlyView.
Overharvesting of wild edible plants poses a growing threat to plant populations worldwide, particularly for slow‐growing species with limited regeneration. We quantified fruit extraction from the third‐largest known population of Jubaea chilensis—an endangered palm endemic to Chile—modeled the critical harvest threshold, and assessed consumer ...
Sebastián Cordero, Francisca Gálvez, Marisol Arriagada‐Honores, Andrés Jesús Garrido, Daniela Paredes‐Muñoz, Bastián Fuentes‐Valdés, Fernanda Torres‐Cifuentes, Francisco E. Fontúrbel   +7 more
wiley   +1 more source