Results 71 to 80 of about 25,236 (218)

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Persistent Organic Pollutants (POPs) and inorganic elements in predatory bird livers and eggs 2007 to 2009: a Predatory Bird Monitoring Scheme (PBMS) Report [PDF]

, 2011
The Predatory Bird Monitoring Scheme (PBMS; http://pbms.ceh.ac.uk/) is the umbrella project that encompasses the Centre for Ecology & Hydrology’s National Capability contaminant monitoring and surveillance work on avian predators.
Beith, S.J., Lawlor, A.J., Moeckel, C., Pereira, M.G., Potter, E.D., Shore, R.F., Walker, L.A.   +6 more
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TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, EarlyView.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

Effects of wind farms on raptors: A systematic review of the current knowledge and the potential solutions to mitigate negative impacts

Animal Conservation, EarlyView.
Our review of 195 studies highlights the consensus on raptors’ avoidance behavior and population decline post‐wind farm installation, emphasizing the significant risks posed by mountaintop wind farms to soaring raptors. Adult raptor mortality, particularly among endangered species, and the elevated collision risks faced by young individuals underscore ...
I. Estellés‐Domingo, P. López‐López   +1 more
wiley   +1 more source

Using Biologics to Reduce Long‐Term Corticosteroid Use in Pyoderma Gangrenosum: Real‐World Evidence From Two Centres

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background Pyoderma gangrenosum (PG) is a challenging inflammatory skin disorder. While corticosteroids offer a rapid response, their long‐term risks necessitate alternative treatments. Objective To compare the long‐term effectiveness of biologic therapies versus systemic corticosteroids in PG management. Methods A retrospective analysis of 15
R. Cascio Ingurgio, A. Alfano, L. Gargiulo, L. Ibba, A. Narcisi, F. Satgé, M. Stark, A. Costanzo, D. F. Murrell   +8 more
wiley   +1 more source

Provision of peri‐operative patient blood management strategies in the UK: a national survey of practice

Anaesthesia, EarlyView.
Summary Introduction In UK hospitals, it is unclear how organisational structures are arranged to support effective implementation of peri‐operative blood management practice strategies. The aim of this study was to conduct a national survey of organisations to describe local practices of peri‐operative patient blood management and infrastructure ...
Samantha R. Warnakulasuriya, Kathleen Wolff, Simon J. Stanworth, on behalf of the Research and Audit Federation of Trainees group and the NIHR BTRU in Data Driven Transfusion Practice Collaborators, Hayley Evans, Alwyn Kotze, Mike Murphy, Antony Palmer, Akshay Shah, Noemie Roy, Martha Belete, William Spencer, Katie Preston, Rebecca Hawes, Reeanne Jones, Murray Williams, Ahmed Ibrahim, Aimi Lara Emilie Jeanes, Akshay Shah, Alan Race, Alexander Bell, Alison Chalmers, Alison Evans, Amarjeet Patil, Amelia Van Manen, Amy Thomas, Anandh Balu, Annette Haines, Annie Smith, Apurva Patil, Ashish Gandhi, Ashley McIlroy, Asya Veloso Costa, Barrie Philip Robertson, Beatrice Meilak, Ben Chandler, Bhavesh Gohil, Carlos Eduardo Abrunhosa de Mattos, Charlotte Katie Morris, Chintan Vora, Chiu Lee, Chris Oscier, Christopher Dixon, Ciara O'Brien, Clare Dallimore, Clare Quaterman, Colette Keenan, Cristian Lasai, Dale Seddon, Daniel Haslam, Darren Caldow, David Perry, Declan Love, Dina Bowey, Earlene Armstrong, Elizabeth Ribey, Emily Yeung, Emma Jacobs, Farzana Begum, Freya Brownlow, Gautam Dhananjay Modak, Gemma Talling, Georgia Monantera, Gomathy Kandasamy, Hannah Houston, Hannah Kennedy, Hannah Louise Headon, Helen Tyler, Henry Sergeant, Ismaa Aslam, Jade Loughran, Jake Melhuish, James Kirkland, James Morris, Jane Doherty, Jennifer Brooke, Jennifer Phillips, Jessica Irwin, Joel Prescott, Jordan McVey, Josephine Barnsley, Ka Po Tam, Katherine Saunders, Kim Rhodes, Krupa Basavaraj, Kush Amin, Laura Carter, Laura Field, Laura Fulton, Laura Scott, Leon Cohen, Louis Murphy, Madeleine Edwards, Madhavi Gudipati, Magde Albarade, Mai Wakatsuki, Manaf Al‐Bayati, Mark Dorrance, Marta Malaj, Matt Bridge, Matthew Peacock, Maya Sussman, Michael Jarvis, Michael Olivier, Mohamed Elbahnasy, Mohammad Sharif, Molly Janowski, Nadeeshya Dulanjalee Welikala, Naomi R C Adey, Nicola Coverdale, Noorunisa Suhail, Oliver Dare, Orlagh McNally, Paul Young, Pei Shan Lim, Peter Sandbach, Philippa Horne, Prathiban Kumar, Puja Chhaniyara, Putri Rimba, Rabia Ghani, Rashmi Rebello, Rebecca Allott, Rebecca Vickers, Richard Timoney, Rishi Naik, Robert Davidson, Robert Palin, Rosanna Seatter, Rotimi Latinwo, Ruchi Maniar, Ryad Sammy Chebbout, Sabba Aziz, Samah Alimam, Samuel Lichfield, Sharon Ramirez, Shashiharen Gnanapandithen, Shashikant Yegnaram, Shriyam Patel, Simon Beecroft, Sioned Elin Davies, Stephanie Worrall, Stuart Cleland, Subhadra Devi Balakrishnan, Suji Pararajasingam, Sumithre Gunathilake, Svetlana Kulikouskaya, Tajwinder Singh Sandhar, Tina Vaz, Toby Reynolds, Tom Kingston, Val Luoma, William Booth, Xiaosu Jiang, Zaid Saghir Ahmed, Zwesty Viera   +155 more
wiley   +1 more source

Global impacts of exotic eucalypt plantations on wildlife

Biological Reviews, EarlyView.
ABSTRACT The establishment of exotic tree plantations poses a pervasive threat to wildlife across the globe. Among the most important tree species used for forestry purposes worldwide are members of the genus Eucalyptus, which have now been established in at least 107 countries outside of their native range.
Maider Iglesias‐Carrasco, Jeannette Torres, Adalid Cruz‐Dubon, Ulrika Candolin, Bob B.M. Wong, Guillermo Velo‐Antón   +5 more
wiley   +1 more source

Contribution of organic farming to conserving and improving biodiversity in Germany – the example avi-fauna [PDF]

, 2006
Although it is the aim of organic farming to increase biodiversity, there is little knowledge about the impact of organic farming on birds. From 2001 to 2003, the number of breeding birds was recorded annually on the organic experimental farm of the ...
Haneklaus, Silvia, Hötker, Hermann, Jeromin, Knut, Paulsen, Hans-Marten, Rahmann, Gerold, Schnug, Ewald, Schrader, Stefan   +6 more
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Emergence, spread, and impact of high‐pathogenicity avian influenza H5 in wild birds and mammals of South America and Antarctica

Conservation Biology, EarlyView.
Abstract The currently circulating high‐pathogenicity avian influenza (HPAI) virus of the subtype H5 causes variable illness and death in wild and domestic birds and mammals, as well as in humans. This virus evolved from the Goose/Guangdong lineage of the HPAI H5 virus, which emerged in commercial poultry in China in 1996, spilled over into wild birds,
Thijs Kuiken, Ralph Eric Thijl Vanstreels, Ashley Banyard, Lineke Begeman, Andrew Breed, Meagan Dewar, Ruben Fijn, Patricia Pereira Serafini, Marcela Uhart, Michelle Wille   +9 more
wiley   +1 more source

ENRON AND INTERNATIONALLY AGREED PRINCIPLES FOR CORPORATE GOVERNANCE AND THE FINANCIAL SECTOR [PDF]

Recent corporate scandals have led to a wide-ranging re-examination of standards for corporate governance with repercussions that extend to financial regulation and the key standards for financial systems which are a major component of current ...
Andrew CORNFORD
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