Results 131 to 140 of about 581,861 (308)

Epithelioid Hemangioendothelioma of Spleen and Bone: A Case Report

Journal of the Belgian Society of Radiology
Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that can originate in various parenchymatous organs, soft tissue, and bone. Extrahepatic involvement is exceedingly rare. In this case, multifocal disease in the spleen and bone was present.
Melvin Denolf, Annelies Rappaport, Sigrun Delvaux   +2 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Characteristics and Treatment Results of 5 Patients with Fibrous Dysplasia and Review of the Literature

Case Reports in Endocrinology, 2015
Aim. Fibrous dysplasia is a rare bone disease caused by missense mutation leading to abnormal fibroblast and osteoblast proliferation and increased bone resorption. FD can present in monostotic or polyostotic forms. About 3% of FD could be in association
Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Emine Kartal Baykan, Serap Baydur Sahin, Fusun Saygili   +4 more
doaj   +1 more source

Cancer in Ancient Human Populations: Methods and Practice in Bioarchaeology and Paleopathology [PDF]

, 2020
Best Undergraduate Writing in Anthropology Award, 2019-2020Despite its prevalence in contemporary public health, research on the paleopathology of cancer is still extremely limited.
Gardner, Elijah
core  

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

A pragmatic patient-reported outcome strategy for rare disease clinical trials: application of the EORTC item library to myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. [PDF]

, 2019
BackgroundNovel, pragmatic, patient-centered strategies are needed to ensure fit-for-purpose patient-reported outcomes (PRO) instruments in clinical trial research for rare diseases such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML ...
Bejar, Rafael, Bell, Jill A, Cano, Stefan, Faller, Douglas V, Fram, Robert J, Galaznik, Aaron, Marquis, Patrick, Pompilus, Farrah, Scipione, Fatima, Strzok, Sara   +9 more
core  

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Healthcare trajectory of children with rare bone disease attending pediatric emergency departments. [PDF]

Orphanet J Rare Dis, 2020
Yang DD, Baujat G, Neuraz A, Garcelon N, Messiaen C, Sandrin A, Cheron G, Burgun A, Pejin Z, Cormier-Daire V, Angoulvant F.   +10 more
europepmc   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source