Results 141 to 150 of about 7,599,301 (308)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
IFLA Rare Books and Special Collections Section events at WLIC 2017
, 2017 The Rare Books and Special Collections Section invites you to join our programme of events during the Congress. Full details of each session are posted on the Congress website but this post gives a short summary. Get involved!
IFLA Rare Books & Special Collections Section
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
IFLA Survey on Rare Materials Cataloguing with RDA
, 2019 Standardized cataloguing of rare materials has always been a complex matter, historically fragmented within geographical regions until the arrival in the 1980s of standardized models, such as ISBD and DCRM, which were quickly adopted internationally.
IFLA Rare Books & Special Collections Section
core
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
A Rare Case Of Pigmented Mammary Paget Disease [PDF]
En Hyung Kim,1,2,* Wonnam Kim,3,* Ji Yeoun Lee1,2 1Department of Dermatology, College of Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea; 2Department of Dermatology, Chungbuk National University Hospital, Cheongju,
Kim EH, Kim W, Lee JY
core
Neurology and TherapyIntroduction Anti-aquaporin-4 antibody-positive (AQP4-Ab+) neuromyelitis optica spectrum disorder (NMOSD) is a complement-mediated autoimmune disease in which unpredictable and relapsing attacks on the central nervous system cause irreversible and ...
Stacey L. Clardy +10 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
, 2016 The National Library of Brazil and the National Rare Books Program Identification (Plano Nacional de Recuperação de Obras Raras), has announced the call for papers to the 12th National Meeting of Rare Books to be held 24th and 25th November 2016.
IFLA Rare Books & Special Collections Section
core