Results 51 to 60 of about 5,710 (256)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Homologació de rareses ornitològiques a Balears. Informe de 2011 [PDF]

Homologació de rareses ornitològiques a Balears. Informe de 2011. 21è informe anual que presenta el comitè de rareses Ornitològiques de Balears. S’han homologat 27 registres, corresponents a les següents espècies, ànnera canyella Tadorna ferruginea ...
García-Febrero, Òscar, Herrero, Carlos, López-Jurado, Carlos, Martínez, Oliver, Nicoll, Steve, Rebassa, Maties   +5 more
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Influence of nutrient substrates on the expression of cellulases in Cerambyx cerdo L. (Coleoptera: Cerambycidae) larvae [PDF]

, 2012
The expression and distribution of digestive cellulases along the midgut of Cerambyx cerdo larvae were analyzed for the first time and are presented in this article.
Dojnov Biljana, Grujić Marica, Ivanović Jelisaveta, Nenadović Vera, Pavlović R., Vujčić Miroslava, Vujčić Z.   +6 more
core   +5 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Numerical analysis of distribution patterns in the British and European floras [PDF]

, 2007
Imperial Users ...
Finnie, Thomas James Ronald, Finnie, Thomas James Ronald   +1 more
core  

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Homologació de rareses ornitològiques a Balears. Informe de 2009 [PDF]

Homologació de rareses ornitològiques a Balears. Informe de 2009. dinovè informe anual que presenta el Comitè de Rareses Ornitològiques del GOB. S’han homologat 31 registres, corresponents a les seguents espècies, de les quals destaca un re gistre ...
Bonnín, Jaume, Comitè de Rareses Ornitològiques a Balears del GOB, Escandell, Raül, López-Jurado, Carlos, Muntaner, Jordi, Rebassa, Maties, Sunyer, Josep   +6 more
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Homologació de rareses ornitològiques a Balears. Informe de 2008 [PDF]

Homologació de rareses ornitològiques a Balears. Informe de 2008. Divuitè informe anual que presenta el Comitè de Rareses Ornitològiques del GOB. S’han homologat 10 registres, hi destaca una homologació feta per primera vegada a les Balears: calàndria ...
Bonnín, Jaume, Escandell, Raül, López-Jurado, Carlos, Muntaner, Jordi, Rebassa, Maties   +4 more
core