Results 71 to 80 of about 968 (191)

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci   +3 more
wiley   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

open access: yesIbrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen   +10 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity   +3 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 296-309, February 2026.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin   +12 more
wiley   +1 more source

Young woman with a four-year history of epilepsy and progressive focal cortical atrophy — What is the diagnosis?

open access: yesEpilepsy and Behavior Case Reports, 2014
The pathogenesis of disease progression in drug-refractory epilepsy is poorly understood. We report the case of a young woman with a four-year history of epilepsy that progressed rapidly as evidenced by the development of progressive focal cortical ...
S. Pati   +4 more
doaj   +1 more source

Predictors of etiology and drug resistance in children with new‐onset focal seizures

open access: yesEpilepsia Open, Volume 11, Issue 1, Page 123-135, February 2026.
Abstract Objective To examine the clinical features of new‐onset focal seizures in children and investigate clinical associations and predictors of underlying etiology and drug resistance. Methods Data were gathered from The Children's Hospital at Westmead admissions for patients aged 1 month to 18 years who presented with new‐onset focal seizures ...
Byoung Chan Lee   +7 more
wiley   +1 more source

Real‐World Use of Cenobamate in Paediatric Drug‐Resistant Epilepsy: Long‐Term Efficacy, Safety, and Co‐Medication Adjustment

open access: yesEuropean Journal of Neurology, Volume 33, Issue 2, February 2026.
Cenobamate demonstrated high efficacy and long‐term retention in 78 children with drug‐resistant epilepsy. A ≥ 50% reduction in seizure frequency was achieved in 67.9% of patients, including 6.4% who became seizure‐free. Treatment was well tolerated and associated with a reduced overall drug load, supporting further prospective validation and ...
Tiziana Pisano   +10 more
wiley   +1 more source

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

open access: yesWIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh   +8 more
wiley   +1 more source

Late Remission of Seizures After Functional Hemispherotomy in a Child With Congenital Middle Cerebral Artery Infarct

open access: yesArchives of Epilepsy, 2017
Hemispherotomy can be a useful procedure in hemispheric syndromes, such as Rasmussen’s encephalitis, congenital stroke, or hemimegalencephaly. The seizures associated with these syndromes usually remit immediately after hemispherotomy.
Uğur IŞIK   +2 more
doaj   +1 more source

Evaluation of the Effect of IL‐1 Antagonists on Pituitary Function

open access: yesInternational Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease frequently observed in populations along the Eastern Mediterranean coast, characterized by recurrent fever, abdominal pain, and joint inflammation. The disease results from mutations in the MEFV gene, which plays a critical role in regulating IL‐1β secretion ...
Fadime Aktas Koc   +3 more
wiley   +1 more source

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