Results 71 to 80 of about 1,158 (166)

Real‐World Use of Cenobamate in Paediatric Drug‐Resistant Epilepsy: Long‐Term Efficacy, Safety, and Co‐Medication Adjustment

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Cenobamate demonstrated high efficacy and long‐term retention in 78 children with drug‐resistant epilepsy. A ≥ 50% reduction in seizure frequency was achieved in 67.9% of patients, including 6.4% who became seizure‐free. Treatment was well tolerated and associated with a reduced overall drug load, supporting further prospective validation and ...
Tiziana Pisano, Simona Balestrini, Alessandra Boncristiano, Saverio Caini, Martina Lombardini, Erica Scuma, Mara Cavallin, Luca Bartolini, Simona Pellacani, Carmen Barba, Renzo Guerrini   +10 more
wiley   +1 more source

Late Remission of Seizures After Functional Hemispherotomy in a Child With Congenital Middle Cerebral Artery Infarct

Archives of Epilepsy, 2017
Hemispherotomy can be a useful procedure in hemispheric syndromes, such as Rasmussen’s encephalitis, congenital stroke, or hemimegalencephaly. The seizures associated with these syndromes usually remit immediately after hemispherotomy.
Uğur IŞIK, Bahattin TANRIKULU, M. Memet ÖZEK   +2 more
doaj   +1 more source

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh, Cinzia Santucciu, Valentina Chisu, Helia Sepahvand, Abbas Rahdar, Razieh Behzadmehr, Octavio Luiz Franco, Guettari Moez, Luiz Fernando Romanholo Ferreira   +8 more
wiley   +1 more source

Evaluation of the Effect of IL‐1 Antagonists on Pituitary Function

International Journal of Endocrinology, Volume 2026, Issue 1, 2026.
Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease frequently observed in populations along the Eastern Mediterranean coast, characterized by recurrent fever, abdominal pain, and joint inflammation. The disease results from mutations in the MEFV gene, which plays a critical role in regulating IL‐1β secretion ...
Fadime Aktas Koc, Baris Sariakcali, Ali Sahin, Vikas Kumar Roy   +3 more
wiley   +1 more source

Surgical Interventions in Rasmussen’s Encephalitis [PDF]

Rasmussen’s encephalitis (RE) is a rare, devastating neurological condition characterized by chronic unihemispheric brain inflammation, refractory epilepsy, and progressive neurological decline and hemiplegia with an etiology that remains elusive and a ...
Ahmad, Marwah Nasir, Alderese, Raghad Abdul Qawi, Almaghrebi, Mayar Sharaf, Almurad, Bader Mahmoud, Hoque, Umaira, Saleh, Dalaa Sheikh, Samy, Mohammed, Thalib, Husna Irfan, Timraz, Jumana Hussain   +8 more
core   +2 more sources

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration [PDF]

, 2014
Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons.
Budhu, Sadna, Cebrián, Carolina, Kanter, Ellen, Loike, John D., Mandelbaum, Jonathan, Mauri, Pierluigi, Scherzer, Clemens R., Steinbeck, Julius A., Studer, Lorenz, Sulzer, David, Vonsattel, Jean P., Zecca, Luigi, Zucca, Fabio A.   +12 more
core   +3 more sources

Activation and Long‐Term Maintenance of Adaptive Immunity in the Central Nervous System: A Double‐Edged Sword?

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
A wide spectrum of cells in the brain can engage in antigen presentation, which activates adaptive immunity in the central nervous system (CNS). Tissue‐resident memory T cells (TRM) develop in adaptive immunity in the CNS and provide long‐term immune surveillance, including the clearance of pathogens and tumor cells.
Luojinyun Wang, Feng Zhang, Jiehong Wu, Sibo Yang, Daqiang Zhou, Xiaodi Sun, Bohao Chang, Bo Hu, Yifan Zhou   +8 more
wiley   +1 more source

Memory Performance is Related to Language Dominance as Determined by the intracarotid amobarbital procedure [PDF]

, 2009
Objective The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.
Alexopoulosa, A. V., Kovac, S., Lineweaver, Tara T., Loddenkemper, T., Möddel, G., Reinholz, J., Schuele, S. U., Syed, T.   +7 more
core   +2 more sources

Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus

Epileptic Disorders, Volume 27, Issue 6, Page 1292-1297, December 2025.
Abstract This case study reports the first documented use of stereoelectroencephalography (SEEG)‐guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33‐year‐old woman with drug‐resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone.
Odile Feys, Julia Makhalova, Thomas Manners, José‐David Herrera‐García, Romain Carron, Fabrice Bartolomei   +5 more
wiley   +1 more source

Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies [PDF]

, 2014
Introduction Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC).
Coppola, A., Coppola, A., Diehl, B., Diehl, B., Liu, J.Y.W., Liu, J.Y.W., Michalak, Z., Michalak, Z., Reeves, C., Reeves, C., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +13 more
core   +1 more source