Results 61 to 70 of about 631,359 (323)

SNVstory: inferring genetic ancestry from genome sequencing data

open access: yesBMC Bioinformatics
Background Genetic ancestry, inferred from genomic data, is a quantifiable biological parameter. While much of the human genome is identical across populations, it is estimated that as much as 0.4% of the genome can differ due to ancestry. This variation
Audrey E. Bollas   +5 more
doaj   +1 more source

In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages

open access: yesOncoImmunology
Glioblastoma (GBM) is the most common primary central nervous system tumor with a dismal prognosis and limited treatment options. Recent success utilizing immunotherapies for treating other solid tumors have been largely unsuccessful in GBM.
Matthew Nazzaro   +8 more
doaj   +1 more source

Homological thickness and stability of torus knots

open access: yes, 2006
In this paper we show that the non-alternating torus knots are homologically thick, i.e. that their Khovanov homology occupies at least three diagonals. Furthermore, we show that we can reduce the number of full twists of the torus knot without changing ...
Dunfield   +8 more
core   +2 more sources

Influence of Zn2+ and Oxygen Supply on Malic Acid Production and Growth of Aspergillus oryzae

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Malic acid is a valuable platform chemical traditionally derived from fossil‐based resources. Microbial cultivation with Aspergillus oryzae offers a sustainable alternative based on renewable feedstocks. In this study, a well‐established minimal medium for malic acid production, commonly used in previous research to ensure reproducibility, was
Lukas Hartmann   +3 more
wiley   +1 more source

Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity

open access: yesBMC Genomics
Background Cancers exhibit complex transcriptomes with aberrant splicing that induces isoform-level differential expression compared to non-diseased tissues.
Saranga Wijeratne   +12 more
doaj   +1 more source

Disputable Issues in the Russian History of the 16th Century

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2019
Knud Rasmussen (1930–1985) was a famous Danish historian, Professor at Institute of Slavic Studies at University of Copenhagen, specialist in medieval Russia, author of a dozen of scientific monographs published in large editions including in Russian. In
Knud Rasmussen (1930–1985)
doaj   +1 more source

Best practices for variant calling in clinical sequencing

open access: yesGenome Medicine, 2020
Next-generation sequencing technologies have enabled a dramatic expansion of clinical genetic testing both for inherited conditions and diseases such as cancer.
Daniel C. Koboldt
doaj   +1 more source

Rasmussen syndrome in a tropical environment: a study of six (6) observations

open access: yesThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization.
Carlos Othon Guelngar   +25 more
doaj   +1 more source

Automated MRI Volumetric Analysis in Patients with Rasmussen Syndrome

open access: yesAmerican Journal of Neuroradiology, 2016
BACKGROUND AND PURPOSE: Rasmussen syndrome, also known as Rasmussen encephalitis, is typically associated with volume loss of the affected hemisphere of the brain.
Z. I. Wang   +12 more
semanticscholar   +1 more source

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan   +7 more
wiley   +1 more source

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