Results 101 to 110 of about 1,677,827 (316)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Introduction of CNC turning machine Okuma IB3000 EX II in Company Kovinarstvo Rožič

open access: yes, 2018
Diplomsko delo predstavlja uvajanje CNC stružnice Okuma LB3000 EX 11 v podjetju Kovinarstvo Rožič. V diplomskem delu je na začetku kratek opis podjetja Kovinarstvo Rožič, nato so predstavljene teoretične osnove CNC obdelovalnih strojev.
Rat, Urban
core  

Social Minima and the Guaranteed Minimum Income Program in Romania, 1995-2024

open access: yesStudia Universitatis Babes-Bolyai Sociologia
The present paper provides a qualitative historical analysis of the evolution of the Guaranteed Minimum Income (GMI) program in Romania between 1995 and 2024 in relation to envisaged social minima.
Raţ Cristina
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Prolonged Radiation Damage in Rat Colon and Urokinase Expression in Epithelium [PDF]

open access: yes, 2001
Although radiation therapy plays important role in the treatment of gynecological tumors, it may cause radiation injury as a late effect. Several recent reports show that urokinase such as urokinase type plasminogen activator (uPA) contributes to the ...
Matsuu, Mutsumi   +6 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Analysis and comparison of software frameworks for data modeling

open access: yes, 2016
V diplomskem delu smo preverili in opisali orodja za generiranje izvorne kode iz podatkovnega modela relacijske baze. Rešitev smo implementirali z vsemi navedeneimi orodji ter primerjali čas in postopek implementacije.
Rat, Boris
core  

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