Results 131 to 140 of about 2,623,004 (310)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceGenome sequence of the Brown Norway rat yields insights into mammalian evolution
Nature, 2004 R. Gibbs, G. Weinstock, M. Metzker, D. Muzny, E. Sodergren, S. Scherer, Graham Scott, D. Steffen, K. Worley, P. Burch, Geoffrey O. Okwuonu, S. Hines, L. Lewis, C. D’Eramo, O. Delgado, S. Dugan-Rocha, George R. Miner, M. Morgan, A. Hawes, Rachel B. Gill, Celera, R. Holt, M. Adams, P. Amanatides, Holly Baden-Tillson, Mary Barnstead, Soo H. Chin, C. Evans, S. Ferriera, C. Fosler, A. Glodek, Z. Gu, D. Jennings, C. Kraft, T. Nguyen, C. Pfannkoch, Cynthia D. Sitter, G. Sutton, J. Venter, T. Woodage, Douglas R. Smith, H. Lee, E. Gustafson, P. Cahill, A. Kana, L. Doucette-Stamm, Keith G Weinstock, K. Fechtel, R. Weiss, D. Dunn, E. Green, R. Blakesley, G. Bouffard, P. D. de Jong, K. Osoegawa, B. Zhu, M. Marra, J. Schein, I. Bosdet, C. Fjell, Steven P. Jones, M. Krzywinski, Carrie A. Mathewson, A. Siddiqui, N. Wye, J. McPherson, Shaying Zhao, C. Fraser, Jyoti Shetty, S. Shatsman, Keita Geer, Yixin Chen, Sofyia Abramzon, W. Nierman, P. Havlak, Rui Chen, K. Durbin, Amy Egan, Yanru Ren, Xing-Zhi Song, Bingshan Li, Yue Liu, X. Qin, S. Cawley, A. Cooney, Lisa M. D'Souza, Kirt A. Martin, Jia Qian Wu, M. Gonzalez-Garay, Andrew R. Jackson, Ken J Kalafus, M. P. McLeod, A. Milosavljevic, D. Virk, A. Volkov, D. Wheeler, Zhengdong D. Zhang, J. Bailey, E. Eichler, Eray Tuzun, E. Birney, Emmanuel Mongin, A. Ureta-Vidal, Cara Woodwark, E. Zdobnov, P. Bork, M. Suyama, D. Torrents, Marina Alexandersson, B. Trask, Janet M. Young, Hui Huang, Huajun Wang, Heming Xing, Sue Daniels, D. Gietzen, Jeanette Schmidt, Kristian Stevens, U. Vitt, J. Wingrove, F. Camara, M. Mar Albà, J. F. Abril, R. Guigó, A. Smit, I. Dubchak, E. Rubin, O. Couronne, Alexander Poliakov, N. Hübner, D. Ganten, Claudia Goesele, O. Hummel, T. Kreitler, Young-Ae Lee, J. Monti, H. Schulz, H. Zimdahl, H. Himmelbauer, H. Lehrach, H. Jacob, Susan Bromberg, J. Gullings-Handley, M. Jensen-Seaman, A. Kwitek, Jozef Lazar, D. Pasko, P. Tonellato, S. Twigger, C. Ponting, José M Duarte, S. Rice, L. Goodstadt, S. Beatson, Richard D Emes, E. Winter, C. Webber, P. Brandt, G. Nyakatura, Margaret Adetobi, Francesca Chiaromonte, L. Elnitski, Pallavi Eswara, R. Hardison, Minmei Hou, Diana L. Kolbe, K. Makova, W. Miller, A. Nekrutenko, C. Riemer, S. Schwartz, James Taylor, Shan Yang, Yi Zhang, K. Lindpaintner, T. Andrews, M. Cáccamo, M. Clamp, Laura Clarke, V. Curwen, R. Durbin, E. Eyras, S. Searle, G. Cooper, S. Batzoglou, M. Brudno, A. Sidow, Eric A. Stone, B. Payseur, G. Bourque, C. López‐Otín, X. Puente, Kushal Chakrabarti, Sourav Chatterji, Colin N. Dewey, L. Pachter, Nicolas L. Bray, V. B. Yap, A. Caspi, G. Tesler, P. Pevzner, D. Haussler, Krishna M. Roskin, R. Baertsch, H. Clawson, T. Furey, A. Hinrichs, D. Karolchik, W. Kent, K. Rosenbloom, Heather Trumbower, M. Weirauch, D. Cooper, P. Stenson, Bin Ma, M. Brent, Manimozhiyan Arumugam, David D. Shteynberg, R. Copley, Martin S. Taylor, H. Riethman, U. Mudunuri, Jane L. Peterson, M. Guyer, A. Felsenfeld, S. Old, Stephen Mockrin, F. Collins +227 moresemanticscholar +1 more sourceMicrobiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille +3 morewiley +1 more sourceComprehensive Pharmacokinetics of the Marine-Derived PDE4 Inhibitor LY104 and Its Major Metabolite M1 in Rats: A Validated LC-MS/MS Method with Sex Comparison, Multiple-Dose, Protein Binding, Metabolic Stability, and Excretion Studies. [PDF]
Mar DrugsNiu X, Zhao J, Ding D, He W, Du G, Hao J, Zhao J. +6 moreeuropepmc +1 more sourceAn epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz +14 morewiley +1 more source
