Results 231 to 240 of about 1,677,827 (316)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The pathophysiological role of MiRNAs in heart failure. [PDF]

Front Cardiovasc Med
Lian K, Qi Q, Meng L, Zhu X, Zhang Y, Xu Y, Song Z, Li L, Hu S, Hu Z.   +9 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Armas de Valencia : resumen de conferencias pronunciadas en Lo Rat Penat por los señores Torres Belda, Vives Ciscar, Tramoyeres y Martinez Aloy

, 1880
Vives Ciscar, José
core  

A validated SSAM-FEA framework for the rat knee reproduces varus-induced contact redistribution in a meniscus-deficient setting. [PDF]

Front Bioeng Biotechnol
Lu K, Tao YR, Guo SH, Li C, Gu XL, Chen B.   +5 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats. [PDF]

Part Fibre Toxicol
Han HY, Hwangbo S, Park EJ, Park SM, Choi MS, Oh JH, Yang MJ, Jung W, Kwak M, Lee TG, Cassee FR, Lu Q, Yoon S.   +12 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Fundamental and unique roles of PLAC1 in the regulation of rat and human trophoblast cell development. [PDF]

Development
Moreno-Irusta A, Urosevic J, Iqbal K, Seetharam AS, Nteeba J, Scott RL, Kuna M, Muto M, Kozai K, Celic A, Okae H, Arima T, Johnson DK, Tuteja G, Soares MJ.   +14 more
europepmc   +1 more source