Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
BMC UrologyBackground Prostate cancer is most commonly diagnosed at a localized stage, allowing the majority of patients to receive curative treatment. The prognosis is often favorable, and there are numerous treatment options available, emphasizing the importance ...
Lauri Mäkelä +3 more
doaj +1 more source
A Rate Function Approach to Computerized Adaptive Testing for Cognitive Diagnosis. [PDF]
Psychometrika, 2015 Liu J, Ying Z, Zhang S.
europepmc +1 more source
Analysis of the rate of convergence of fully connected deep neural\n network regression estimates with smooth activation function [PDF]
, 2020 Sophie Langer
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Reliability analysis using an exponential power model with bathtub-shaped failure rate function: a Bayes study. [PDF]
Springerplus, 2016 Shehla R, Khan AA.
europepmc +1 more source
Rate of Decline in Kidney Function and Age-of-Onset or Duration of Type 2 Diabetes [PDF]
, 2021 Oyunchimeg Buyadaa +4 more
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Semiparametric Stochastic Modeling of the Rate Function in Longitudinal Studies. [PDF]
J Am Stat Assoc, 2011 Zhu B, Taylor JM, Song PX.
europepmc +1 more source