Results 201 to 210 of about 9,390,253 (340)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Renal Function Outcomes in Tuberous Sclerosis Complex Patients Receiving Everolimus for Renal Angiomyolipoma. [PDF]

Eur Urol Open Sci
Liao Z, Wang W, Zhao Y, Liu Y, Qiu D, Zhang Y.   +5 more
europepmc   +1 more source

Cardiovascular function in transgender women on hormone therapy: the role of circulatory Power, Rate-pressure product, and blood pressure responses to exercise [PDF]

Fabrício Braga, Juliana Goulart Prata Oliveira Milani, Maurício Milani, Ana Carolina Fachetti, Bruna Kalichsztein, Roberto Zagury, Karen De Marca, Rossano Kepler Alvim Fiorelli, Dominique Hansen, Gerson Cipriano, Ricardo Mourilhe‐Rocha   +10 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Correction: The rise of rat models for Duchenne muscular dystrophy and therapeutic evaluations. [PDF]

Skelet Muscle
Relaix F, Lafuste P, Taglietti V, Tiret L.   +3 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The impact of heart rate on echocardiographic measures of left ventricular function: novel insights facilitated by deep learning. [PDF]

Eur Heart J Imaging Methods Pract
Woelfert A, Mjølstad OC, Dale AC, Salvesen Ø, Lovstakken L, Dalen H, Østvik A, Grenne B.   +7 more
europepmc   +1 more source

Effects of Aging on Perceptual and Electrophysiological Responses to Acoustic Pulse Trains as a Function of Rate

, 2019
Casey R. Gaskins, Brittany N. Jaekel, Sandra Gordon‐Salant, Matthew J. Goupell, Samira Anderson   +4 more
openalex   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Brain Amyloid Plaque Levels Affect Clinical Progression in Alzheimer Disease: Assessment of Amyloid PET and Change in CDR-SB Utilizing Semi-Mechanistic Model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bhagunde P, Penner N, Willis BA, Bell R, Charil A, Irizarry MC, Hersch S, Reyderman L.   +7 more
europepmc   +1 more source