Exploring opportunities to integrate climate change into Gross National Happiness for Bhutan and its application for global wellbeing-centred Climate Resilient Development. [PDF]
Environ ManageDorji T, Morrison-Saunders A, Blake D.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Econometric Analysis of Realised Covariation: High Frequency Covariance, Regression and Correlation in Financial Economics [PDF]
This paper analyses multivariate high frequency financial data using realised covariation. We provide a new asymptotic distribution theory for standard methods such as regression, correlation analysis and covariance.
Neil Shephard, Ole E. Barndorff-Nielsen
core
Study on the Characteristics of MBN and MAE Signals in P92 Steel. [PDF]
Materials (Basel)Huang Z +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Experimental verification of DAS vibration response characteristics of equal strength beam under sinusoidal excitation. [PDF]
Sci RepMa C, Chai J, Zhang D, Li Z, Gao L.
europepmc +1 more source
Influence of voltage frequency and rate of change on internal partial discharges
, 2022 Interne, partielle utladninger i elektriske maskiner utgjør en betydelig kilde til degradering og havari. Høyspentmaskiner blir i økende grad utsatt for raske, repetitive spenningspulser forårsaket av transistor-switching i kraftelektronikk. En grundigere forståelse av hvordan slike høyspentpulser påvirker adferden til partielle utladninger er derfor ...
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Validating free spectral range tracking as a robust method for mitigating artifacts in VSC kinetics. [PDF]
RSC AdvGu K, Zhao X, Peng R, Zhang F.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source