Results 61 to 70 of about 166,352,380 (305)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
International Journal of Mathematics and Mathematical Sciences, 1996 In this paper a uniform estimate is obtained for the remainder term in the central limit theorem (CLT) for a sequence of random vectors forming a homogeneous Markov chain with arbitrary set of states.
M. Gharib
doaj +1 more source
Calculating the Weighted Moore–Penrose Inverse by a High Order Iteration Scheme
Mathematics, 2019 The goal of this research is to extend and investigate an improved approach for calculating the weighted Moore−Penrose (WMP) inverses of singular or rectangular matrices. The scheme is constructed based on a hyperpower method of order ten.
Haifa Bin Jebreen
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Convergence Rate Analysis of MAP Coordinate Minimization Algorithms
, 2019 Finding maximum a posteriori (MAP) assignments in graphical models is an important task in many applications. Since the problem is generally hard, linear programming (LP) relaxations are often used.
Meshi, Ofer +2 more
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On the Bounds for a Two-Dimensional Birth-Death Process with Catastrophes
Mathematics, 2018 The model of a two-dimensional birth-death process with possible catastrophes is studied. The upper bounds on the rate of convergence in some weighted norms and the corresponding perturbation bounds are obtained.
Anna Sinitcina +9 more
doaj +1 more source
On the rate of convergence for a class of Markovian queues with group services
Discrete and Continuous Models and Applied Computational Science, 2020 There are many queuing systems that accept single arrivals, accumulate them and service only as a group. Examples of such systems exist in various areas of human life, from traffic of transport to processing requests on a computer network. Therefore, our
Anastasia L. Kryukova
doaj +1 more source