Results 131 to 140 of about 167,647,873 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Competing for FutureGen a win-win for Ohio.

, 2006
Interim report.; Title from PDF caption (viewed Sept. 13, 2006).; "Created: 7/20/2006 ..."--Document properties screen.; Harvested from the web on 9/13/06A summary of the positive benefits of the FutureGen competition already being realized in Ohio, as ...
Ohio FutureGen Task Force.
core  

2023 Joint Report on Multilateral Development Banks Climate Finance [PDF]

This 13th edition of the Joint Report on Multilateral Development Banks Climate Finance is an overview of climate finance committed in 2023 by the African Development Bank (AfDB), the Asian Development Bank (ADB), the Asian Infrastructure Investment Bank
Inter-American Development Bank
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Association between hip and trunk muscle strength and modified single-leg horizontal jump test performance in elite team handball players

Frontiers in Sports and Active Living
IntroductionAssessing unilateral jumping performance and its determinants is important in handball, as it underpins key offensive and defensive actions.
Primož Pori, Nejc Šarabon, Nejc Šarabon, Marko Šibila, Darjan Spudić   +4 more
doaj   +1 more source

IDB Newsletter: Vol. 7, no. 3, July 1969

, 1969
IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

AI-Enhanced Prediction of Peak Rate of Torque Development from Accelerometer Signals

Applied Sciences
This study explores the use of accelerometer signals as the predictors of Rate of Torque Development (RTD) using an artificial neural network (ANN) prediction model.
Victor R. A. Cossich, Larry Katz, Conrado T. Laett   +2 more
doaj   +1 more source

Decomposing changes in the aggregate labor force participation rate [PDF]

This paper presents a simple methodology for decomposing changes in the aggregate labor force participation rate (LFPR) over time into demographic group changes in labor force participation behavior and in population share. The purpose is to identify the
Julie L. Hotchkiss
core