Results 241 to 250 of about 21,832,942 (335)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Burden of neural tube defects in the Middle East and North Africa from 1990 to 2021: Findings from the global burden of disease study. [PDF]

J Taibah Univ Med Sci
Babaei-Ghazani A, Soleymanzadeh H, Kariznoee H, Ansari H, Farhadi F, Danandeh K, Seyedmirzaei H, Nakhostin-Ansari A.   +7 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Adolescent pregnancy estimates, spatial distribution, and policy implications in the Volta Region, Ghana, 2019-2023. [PDF]

Sci Rep
Kubio C, Abanga WA, Zeng V, Bosoka SA, Afetor M, Aklikpe I, Klu D, Djokoto SK, Baiden F.   +8 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

A Glutamatergic Medial Prefrontal Cortex-Locus Coeruleus Circuit Drives Intestinal Dysmotility in Diarrhea-Predominant Irritable Bowel Syndrome. [PDF]

Int J Mol Sci
Jia SM, Wang KQ, Hu SF, Weng RX, Liu K, Sun Q, Li R.   +6 more
europepmc   +1 more source

Clinical efficacy of MWA via the caudal‒cranial direction puncture pathway for small hepatocellular carcinoma at the hepatic dome: 3 years of follow-up. [PDF]

BMC Surg
Tang WG, Xu JJ, Liu Y.
europepmc   +1 more source

The added value of distal radius bone mineral density for the diagnosis of osteoporosis in patients with a history of fragility fracture. [PDF]

BMC Musculoskelet Disord
Heydari P, Mirzaei A, Tabrizian P, Zabihiyeganeh M.   +3 more
europepmc   +1 more source

Solar radiation differences drive karst sun and shade leaf carbon sink contribution shifts. [PDF]

Carbon Balance Manag
Du J, Wu L, Wei H, Chen D, Yang D, Xiong L, Xia Y.   +6 more
europepmc   +1 more source