Results 121 to 130 of about 45,639 (357)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

Validity of Retrospective Session Rating of Perceived Exertion to Quantify Training Load in youth Athletes

Journal of Strength and Conditioning Research, 2017
Scantlebury, S, Till, K, Sawczuk, T, Phibbs, P, and Jones, B. Validity of retrospective session rating of perceived exertion to quantify training load in youth athletes.
S. Scantlebury, K. Till, T. Sawczuk, P. Phibbs, B. Jones   +4 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Effects of Backpack Load and Trekking Poles on Energy Expenditure During Field Track Walking [PDF]

, 2018
This study evaluates the effects of the use of backpack load and trekking poles on feld track walking energy expenditure. Twenty male volunteer pole walkers (age: 22.70 ± 2.89 years; body mass: 77.90 ± 11.19 kg; height: 1.77 ± 0.06 m; percentage of body ...
Brito, João, de Araújo Junior, Adenilson, Garrido, Nuno Domingos, Hopffer Romero, Félix Luís, Reis, Victor   +4 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Efeito da ordem dos exercícios sobre o desempenho durante uma sessão de treinamento resistido no método circuito

Revista Brasileira de Cineantropometria e Desempenho Humano, 2014
The aim of this study was to compare total work volume, number of repeti-tions and rate of perceived effort performed in two different sequences of circuit training sessions. Eleven recreationally trained men (24.0 ± 4.8 years, 76.1 ± 8.5 kg, 1.75 ± 0.06
André Luiz Torres Pirauá, Natália Barros Beltrão, Dalton Roberto Alves Araújo de Lima Júnior, Gregório Reis de Queiroz, Jefferson Gomes de Souza, Bruno Machado Melo, Rodrigo Cappato de Araújo   +6 more
doaj   +1 more source

Effects of synchronous music on 400-metre sprint performance [PDF]

, 2006
The aim of the present study was to assess the effects of motivating and oudeterous (neither motivating nor demotivating) synchronous music on 400-m sprint performance while controlling for the potential confound of pre-performance mood.
Karageorghis, CI, Simpson, SD
core