Results 131 to 140 of about 64,029 (389)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Effects of Acute Red Spinach Powder (VitaSpinach^®) Ingestion on Muscular Endurance and Resistance Exercise Performance

Muscles
Introduction: Red spinach powder (RSP) contains high amounts of inorganic nitrate/nitrite (NO3/NO2), which has been suggested to alter vascular activity, cognitive processing, and sprint exercise performance.
Haley M. Nguyen, Sophia L. Porrill, Rebecca R. Rogers, Josselyn Jose-Gomez, Rachel E. Wright, Phoebe N. Spears, Christopher G. Ballmann   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Concurrent validation of the resistance intensity scale for exercise for monitoring velocity-based training with elastic bands

Heliyon
The aim was to evaluate the concurrent validity and reliability of the Resistance Intensity Scale for Exercise [RISE], which uses verbal descriptors, to quantify the intensity in velocity-based training with elastic bands.
Juan C. Colado, Javier Gene-Morales, Pablo Jiménez-Martínez, Angel Saez-Berlanga, Ana María Ferri-Caruana, Amador Garcia-Ramos, Jorge Flandez, Carlos Babiloni-Lopez   +7 more
doaj   +1 more source

Efeito da ordem dos exercícios sobre o desempenho durante uma sessão de treinamento resistido no método circuito

Revista Brasileira de Cineantropometria e Desempenho Humano, 2014
The aim of this study was to compare total work volume, number of repeti-tions and rate of perceived effort performed in two different sequences of circuit training sessions. Eleven recreationally trained men (24.0 ± 4.8 years, 76.1 ± 8.5 kg, 1.75 ± 0.06
André Luiz Torres Pirauá, Natália Barros Beltrão, Dalton Roberto Alves Araújo de Lima Júnior, Gregório Reis de Queiroz, Jefferson Gomes de Souza, Bruno Machado Melo, Rodrigo Cappato de Araújo   +6 more
doaj   +1 more source

Can Trained Runners Effectively Attenuate Impact Acceleration During Repeated High-Intensity Running Bouts? [PDF]

, 2015
The purpose of this study was to investigate the effects of prolonged high intensity running on impact accelerations in trained runners. Thirteen male distance runners completed two 20-minute treadmill runs at speeds corresponding to 95% of onset of ...
Clansey, AC, Feehally, T, Hanlon, M, Lake, MJ, Wallace, ES   +4 more
core   +2 more sources

The place of perceived exertion ratings in exercise prescription for cardiac transplant patients before and after training. [PDF]

, 1996
Roy J. Shephard, T. Kavanagh, Donald J. Mertens, M Yacoub   +3 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The effects of man-marking on work intensity in small-sided soccer games [PDF]

, 2012
The aim of this study was to examine the effect of manipulating defensive rules: with and without man-marking (MM and NMM) on exercise intensity in 3 vs. 3 small-sided games (SSGs). Twelve adolescent soccer players (age: 16.2 ± 0.7 years; body mass: 55.7
Carling, C., Chan, G-S.,, Ngo, J.K., Smith, A.W., Tsui, M-C., Wong, D.P   +5 more
core   +1 more source