Results 141 to 150 of about 1,512,358 (286)

Validation of the Norwegian version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale. [PDF]

Clin Park Relat Disord
Alves G, Sørenes YS, Frantzen VH, Gjerstad MD, Bjørnestad AL, Maple-Grødem J, Forsaa EB, Hiorth YH, Herlofson K, Benjaminsen E, Bjørnarå KA, Dietrichs E, Balestrino R, Gasca-Salas C, Lin CR, Sanchez-Ferro A, Tosin MHS, Mestre TA, Kurtis MM, Martinez-Martin P, Luo S, Yu L, Stebbins GT, Goetz CG, MDS COA Translation Steering Committee.   +24 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Neural and biomarker correlates of the Parkinson's Disease-Cognitive Rating Scale in Huntington's disease. [PDF]

Neuroimage Rep
Martinez-Horta S, Puig-Davi A, Sampedro F, Pérez-Pérez J, Franch-Martí C, Olmedo-Saura G, Rivas-Asensio E, Vazquez-Oliver A, Pérez-Carasol L, Horta-Barba A, Pagonabarraga J, Kulisevsky J.   +11 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Validation of the Korean Moss Attention Rating Scale in Traumatic Brain Injury: Reliability and Validity. [PDF]

Korean J Neurotrauma
Jeong SH, Won JH, Oh BM, Kim JJ, Leigh JH, Shin G, Lee S, Lee HY.   +7 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A primer on reliability testing of a rating scale. [PDF]

Indian J Psychiatry
Menon V, Grover S, Gupta S, Indu PV, Chacko D, Vidhukumar K.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Validity and Reliability of the Transactional EXchanges in Texting for Aphasia Rating Scale. [PDF]

J Speech Lang Hear Res
Lee JB, Azios JH, Fergadiotis G, McMahon MF, Cherney LR.   +4 more
europepmc   +1 more source