Results 191 to 200 of about 3,665,294 (312)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Inorganic carbon transported into the Gulf of Trieste by rivers draining karstic areas

Rivers act as important sources of carbon dioxide (CO2) to the atmosphere, playing an important role in changing the estuarine carbonate system. Rivers and underwater springs draining carbonate watersheds deliver freshwater into the Gulf of Trieste (GoT)
De Vittor C., Giani M., Retelletti Brogi S., Laudicella V. A., Douss N., Bazzaro M., Relitti F., Pavoni E., Ogrinc N., Krajnc B., Kralj M., Covelli S.   +11 more
core  

Signal mining and analysis of adverse events in children using growth hormones: A retrospective real-world study based on FAERS. [PDF]

Medicine (Baltimore)
Xu W, Bao J, Fei Y.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Deleterious impact of obstructive sleep apnea on autonomic nervous system control during rapid-eye-movement sleep in adult type 1 diabetes. [PDF]

Physiol Rep
Faivre M, Gouzi F, Ayoub B, Myzia J, Villard O, Suc A, Hayot M, Roubille F, Dauvilliers Y, Thireau J, Bughin F.   +10 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Ester-Bond-Cleavable Self-Degradable Gel Particles for Temporary Plugging and Controlled Deplugging in Multi-Fracture Reservoir Systems. [PDF]

Molecules
Li Z, Qu Y, Han L, Wang G.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Outcomes of EKOS (Ultrasound-Assisted Thrombolysis) for Intermediate-High-Risk Pulmonary Embolism: A PERT-Guided Cohort Study. [PDF]

Interdiscip Cardiovasc Thorac Surg
Ali MNHE, Zayat R, Hatam N, Greven J, Nies J, Mohammed AFA, Kersten A, Marx N, Dreher M, Shieba Y, Spillner J, Kalverkamp S.   +11 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source