Results 141 to 150 of about 52,765 (246)

Prevalence of Phelan McDermid Syndrome Estimated To Be ~1:7300 Using a Multisource Model

Autism Research, EarlyView.
ABSTRACT Estimating the prevalence of genetic disorders is complicated by many factors including sampling bias and differing methods of estimation. However, establishing the true prevalence of these disorders is critical for understanding disease burden, pharmacoeconomic modeling, and resource allocation for testing and care.
Tess Levy, David Lapidus, Kate Friedman, Paige Siper, Larry Glass, Liza Squires, Mary Hames, Joseph D. Buxbaum, Genetic Testing Consortium, Brooklynn Gasser, Meghan Towne, Behrang Mahjani, Seulgi Jung, Stuart Schwartz, Kai Lee Yap, Mindy Li, Avinash V. Dharmadhikari, Gordana Raca, Dolores B. Estrine, Stefanie Biller, Amanda Singleton, Sarah Poll, Alexander Kolevzon   +22 more
wiley   +1 more source

From authorisation to clinical practice: evolution of the use of biological medicines according to the SmPC and guidelines (2006 to 2025). [PDF]

Eur J Clin Pharmacol
Penninx BMF, Hollak CEM, Tas SW, Timmers L, de Visser SJ, van Kempen ZLE.   +5 more
europepmc   +1 more source

Identifying Unique Subgroups of Emotional and Behavioral Presentations in a Large Inpatient and Community Sample of Autistic Youth

Autism Research, EarlyView.
ABSTRACT Autistic youth exhibit wide variability in emotional and behavioral challenges, yet few studies have identified meaningful subgroups based on these profiles. This study applied a random forests ensemble clustering algorithm to item‐level parent‐report data from the Emotion Dysregulation Inventory (EDI) and the Child Behavior Checklist (CBCL ...
Safaa Eldeeb, Jessie Northrup, Caitlin Conner, Shalini Sivathasan, Ligia Antezana, Matthew Siegel, Carla Mazefsky   +6 more
wiley   +1 more source

German Clinical Practice Guideline on Microhematuria in Children and Young Adults: Evaluating Early Detection of Kidney Disease. [PDF]

Kidney Int Rep
Latta K, Boeckhaus J, Weinreich I, Borisch A, Müller D, Kaufmann S, Mentzel HJ, Vauth F, Göbel H, Furtwängler R, Meier M, Bergmann C, Hoefele J, Weinmann-Menke J, Fünfstück R, Jordans I, Wagner C, Büscher A, Rother A, Gross O.   +19 more
europepmc   +1 more source

Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender

Autism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) frequently experience elevated emotional and behavioral difficulties, yet factors associated with variability remain incompletely understood. Adaptive functioning and sensory processing differences have been linked to behavioral problems, but little is known about whether associations differ between
Cory Shulman, Danielle Bitton, Zili Nir
wiley   +1 more source

Developing a framework for pharmaceutical care practices of herbal and dietary supplements in hospital settings: a mixed methods approach. [PDF]

BMC Complement Med Ther
Paisansirikul A, Tangkiatkumjai M.
europepmc   +1 more source

DEMOCRATIC LEGITIMACY - Working agreement or rational consensus?

, 2006
The quest for deliberative democracy is connected to the difficulties with what we for the sake of simplicity refer to as a voting model of democracy.1 This model holds elections and votes as the central features of democracy because they establish egalitarian structures of decision-making.
openaire   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Current Status of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: An International Perspective Including Japan. [PDF]

J Neuroendovasc Ther
Kawakami M, Sugiu K, Hiramatsu M, Haruma J, Kimura R, Soutome Y, Fujita J, Hirata Y, Baba F, Tanaka S.   +9 more
europepmc   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source