Development of the Rational Thinking, Emotion Regulation, and Problem-Solving Mental Fitness Mobile App for US Navy Sailors: Qualitative and Quantitative Usability Evaluation. [PDF]
JMIR Form ResCenkner DP +8 more
europepmc +1 more source
Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
The first formal report on the design, implementation, and evaluation of the objective structured clinical examination (OSCE) to assess the clinical skills of clinical psychology students in Iran. [PDF]
BMC Med EducTaghavi ZAHST, Vatanpour M, Pahlevan M.
europepmc +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Addressing Academic Stress in Secondary Education: A Systematic Review of Intervention Approaches and Related Outcomes. [PDF]
Healthcare (Basel)González-Afonso MC +3 more
europepmc +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Treating emotional pains in parents of children with hearing impairment. [PDF]
Medicine (Baltimore)Aneke A +9 more
europepmc +1 more source
Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes
Advanced Science, EarlyView.The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu +5 more
wiley +1 more source
Effect of religious and spiritual interventions on anxiety, depression, and stress: A systematic review and meta-analysis of randomized clinical trials. [PDF]
J Educ Health PromotAmiri S +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian +8 more
wiley +1 more source