Results 81 to 90 of about 505,503 (271)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

UAV AND GIS BASED TOOL FOR COLLECTION AND PROPAGATION OF SEEDS MATERIAL – FIRST RESULTS [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
Seed management carried out by The State Forests National Forest Holding is an integral part of rational forest management. Seed collection takes place mainly from stands belonging to first category of forest reproductive material, which is the largest ...
K. Stereńczak   +6 more
doaj   +1 more source

Some properties of the k-dimensional Lyness' map

open access: yes, 2008
This paper is devoted to study some properties of the k-dimensional Lyness' map. Our main result presentes a rational vector field that gives a Lie symmetry for F.
Abraham R   +21 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

On the remarkable values of the rational first integrals of polynomial vector fields

open access: yesJournal of Differential Equations, 2007
Let \(X= (P,Q)\) be a polynomial vector field of degree \(m\) on \({\mathbb C}^2\), i.e. a vector field of the form \[ X = P(x,y) \frac{\partial}{\partial x} + Q(x,y) \frac{\partial}{\partial y}, \] where \(P\) and \(Q\) are coprime polynomials in the ring \({\mathbb C}[x,y]\) and \(m = \max \{\deg P, \deg Q\}\).
Ferragut, Antoni, Llibre, Jaume
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Closed-Form Expressions for Irradiance from Non-Uniform Lambertian Luminaires Part I: Linearly-Varying Radiant Exitance [PDF]

open access: yes, 2000
We present a closed-form expression for the irradiance at a point on a surface due to an arbitrary polygonal Lambertian lurninaire with linearly-varying radiant exitance.
Arvo, James, Chen, Min
core   +5 more sources

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