Humanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder. [PDF]
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Congenital Hydrocephalus Revealed in the Inbred Rat, LEW/Jms
Neurosurgery, 1983We studied the development of congenital hydrocephalus found in a colony of an inbred strain of Wistar-Lewis rats (LEW/Jms) at various intervals after birth. The disorder was transmitted as a simple recessive mendelian character. Hydrocephalic neonates were recognized 2 days after birth by stretching of the skin over the head.
Koji Furuya +2 more
exaly +4 more sources
Prenatal aqueductal stenosis as a cuase of congenital hydrocephalus in the inbred at LEW/Jms
Child's Nervous System, 1991We studied the microscopic morphological changes in congenital hydrocephalus in the inbred rat, LEW/Jms, on gestational days 17, 18, and 20 and during the neonatal period to clarify the etiopathogenesis, focusing particularly on the aqueductal changes. At 1 day of age, ventriculomegaly was limited to the lateral and III ventricles, and the aqueduct was
Shizuo Oi, S Matsumoto, Oi Shizuo
exaly +4 more sources
The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes, which arose through a spontaneous mutation in the Dock8 gene within the MHC congenic background strain LEW.1AR1. This mutation not only mediates diabetes development but also leads to a variable T cell frequency in peripheral blood.
Tanja Arndt +2 more
exaly +4 more sources
We studied the microscopic morphological changes on the congenital hydrocephalus in the inbred rat, LEW/Jms in the newborn and the gestational day 20, 18 and 17 to clarify the etiology especially focusing on the aqueductal change by sagittal section. At 1 day old, hydrocephalus was not clear by outer appearance, however, it was evident by sectioning ...
Takayuki Shirakuni +2 more
exaly +3 more sources
The vascular apparatus in congenitally hydrocephalic rat brains was studied. The characteristic findings were structural changes in the small vessels with formation of an intracerebral cavity in the periventricular white matter. Stenotic or occluded blood vessels were located in an edematous area adjacent to the dilated lateral ventricles.
Kazuo Hashi, Yasutaka Kurokawa
exaly +3 more sources
Morphological Study on Congenital Hydrocephalus of the Inbred Rat, LEW/Jms
1990The morphological changes of the cerebral gray matter in congenital hydrocephalic rat were studied. Dilatation of the ventricle with thinned cerebral mantle was observed. The characteristic finding was the “intracerebral cavity formation” in the gray matter as well as in the cerebral white matter.
Tohru Okuyama +4 more
exaly +2 more sources