Results 151 to 160 of about 579,996 (261)

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, Volume 13, Issue 46, 17 August 2026.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, Volume 13, Issue 45, 13 August 2026.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Isomer-Dependent Pharmacokinetic Behavior and VKOR Interactions of Second-Generation Anticoagulant Rodenticides: An Integrated In Vivo-In Vitro-In Silico Investigation. [PDF]

Int J Mol Sci
Miyamae M, Nagaoka S, Hayama T, Fukamatsu M, Kamata R, Takeda K.   +5 more
europepmc   +1 more source

Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking

Archives of Insect Biochemistry and Physiology, Volume 122, Issue 4, August 2026.
Optimized extracts from Ficus carica pruning waste exhibit strong biological activity against major stink bug pests. Complementary in silico analyses suggest this efficacy relies on pest‐specific acetylcholinesterase inhibition, predicting a promising, pollinator‐safe alternative for sustainable agriculture.
Thais A. Almeida, Arley R. Páez, Lara T. M. Costa, Guy Smagghe, Yara M. Cardoso, Letícia M. Faria, Eugênio E. Oliveira, João Paulo V. Leite   +7 more
wiley   +1 more source

HIF‐1α and HIF‐2α Are Upregulated in the Hippocampus but Not in the Medial Prefrontal Cortex in Experimental PTSD

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Post‐traumatic stress disorder (PTSD) is a psychiatric disorder characterized by anxiety, abnormal stress responses, and pathological memory formation. Research indicates that hypoxia‐inducible pathways might influence the neurobiology of PTSD.
Denys Porkhalo, Denis Pashevin, Yana Naumenko, Victor Dosenko   +3 more
wiley   +1 more source

Residual bile flow shapes PPARγ-mediated antifibrotic responses in experimental segmental cholestasis. [PDF]

Sci Rep
Gonçalves JO, Mafra CAM, Castro I, Cogliati B, Bando SY, Teodoro WR, Serafini S, Ferreira LF, Moreira-Filho CA, Tannuri U, Tannuri ACA.   +10 more
europepmc   +1 more source

Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of XuanShi Choudong Recipe in the Treatment of Tic Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
Using an integrated strategy of network pharmacology and transcriptomics, this study elucidates the therapeutic mechanism of XuanShi Choudong Recipe (CDR) against tic disorder (TD). CDR dose‐dependently alleviates apomorphine‐induced tic‐like stereotypy and hyperlocomotion in rats, restores striatal neurotransmitter homeostasis, and attenuates ...
Hu Jue, Ma Jingying, Chen Yaqin, Pan Yulu, Chen Yanhong, Xu Jiaye, Chen Danfei, Chen Jian, Xuan Xiao‐bo   +8 more
wiley   +1 more source

Mammal-infecting DNA viruses identified in lemurs and rodents in Madagascar mirror the evolutionary history of their hosts. [PDF]

Microb Genom
Paietta EN, Johnston RA, Kraberger S, Randrianarisoa SF, Razanamahenina TT, Ramboninarimalala A, Velontsara JB, Raherinirina TG, Raveloson L, Finley NL, Baitchman E, McAdoo BG, Yoder AD, Varsani A.   +13 more
europepmc   +1 more source

Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick‐borne filarial nematode transmission

Biological Reviews, Volume 101, Issue 4, Page 1779-1792, August 2026.
ABSTRACT Tick‐borne filarial nematodes are a complex and understudied group of parasites that rely on ticks for transmission in vertebrates. This review examines how intrinsic and extrinsic factors may influence the successful transmission of filarial nematodes in tick vectors, drawing insights from extensively studied haematophagous dipteran vector ...
Oluwaseun D. Ajileye, Gabriel L. Hamer, Sarah A. Hamer, Guilherme G. Verocai, Jessica E. Light   +4 more
wiley   +1 more source

Prevalence of zoonotic nematode <i>Calodium hepaticum</i> varies with small mammal community diversity across a heterogenous landscape in Eastern Uganda. [PDF]

Parasitology
Johnson E, Ajambo D, Capstick M, Arinaitwe M, Ericsson O, Besigye F, Raghwani J, Dennis TPW, Bogere R, Nankasi A, Atuhaire A, Rowell C, Namukuta A, Mohamed A, Adriko M, Lamberton P, Tukahebwa E, Allan KJ, Faust C.   +18 more
europepmc   +1 more source