Results 41 to 50 of about 600,035 (269)

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Patterns of helminth infections in Rattus rattus and Mus musculus from two Mayan communities in Mexico

, 2019
The black rat Rattus rattus and the house mouse Mus musculus are two commensal rodent species that harbour and shed zoonotic pathogens, including helminths.
Panti May, Jesús Alonso, Robles, Maria del Rosario, Hernández Betancourt, S. F., Palomo Arjona, E. E., Machain Williams, Carlos, Barrientos Medina, R. C., Gurubel González, Y. M., Digiani, Maria Celina   +7 more
core   +1 more source

Zoonotic nematode in the city of La Plata, Argentina: Report of a case of Calodium hepaticum in Rattus rattus [PDF]

, 2023
This study describes a case of Calodium hepaticum (Trichinellida: Capillariidae) infection in an adult rat (Rattus rattus) from the periurban area of the city of La Plata in the province of Buenos Aires, Argentina.
Steffen, Kevin Denis, Robles, Maria del Rosario, Unzaga, Juan Manuel, Moré, Gastón, Basset, Carina Mabel, Moré, Gastón Andrés, Arias, Rubén Omar, Basset, Carina   +7 more
core   +1 more source

Rattus rattus rattus (Linnaeus 1758

, 2018
Rattus rattus (Linnaeus, 1758) Common name: Black rat. Diagnosis: Ears large and rounded. Fur color very variable, ranging from blackish dorsally to grayish to brownish, with the underside being lighter (Figure 74). Head-body length up to 200 mm. Tail longer than head and body length. Little and short hair on tail.
Amr, Zuhair S., Abu, Mohammad A., Qumsiyeh, Mazin, Eid, Ehab   +3 more
openaire   +2 more sources

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis [PDF]

, 2009
Zoonotic visceral leishmaniasis (ZVL) caused by Leishmania infantum is an important disease of humans and dogs. Here we review aspects of the transmission and control of ZVL.
Courtenay, Orin, Quinnell, Rupert J., Quinnell, RJ, Courtenay, O   +3 more
core   +1 more source

Broad and flexible stable isotope niches in invasive non-native Rattus spp. in anthropogenic and natural habitats of central eastern Madagascar

BMC Ecology, 2017
Background Rodents of the genus Rattus are among the most pervasive and successful invasive species, causing major vicissitudes in native ecological communities.
Melanie Dammhahn, Toky M. Randriamoria, Steven M. Goodman   +2 more
doaj   +1 more source

EFFICIENCY OF CERTAIN CHEMICAL COMPOUNDS AGAINST THE CLIMB RAT Rattus rattus alexandrine Under Laboratory Conditions [PDF]

Journal of Plant Protection and Pathology, 2012
Laboratory studies were applied to investigate  the efficiency of bromadiolone 0.005%, vitamins (A, C and E) and bromadiolone 0.005% with vitamin E; on the both sexes of climb.
M. Wilson, A. Abou-Hashem, T. Keshta, A. Asran   +3 more
doaj   +1 more source