Results 131 to 140 of about 877,477 (319)

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

open access: yesFEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He   +5 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

"Sweetwoods" Lignin as Promising Raw Material to Obtain Micro-Mesoporous Carbon Materials. [PDF]

open access: yesMaterials (Basel), 2023
Plavniece A   +6 more
europepmc   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Numerical analysis of building damage caused by the exposure of a terrain threshold as a result of underground mining-induced subsidence

open access: yesScientific Reports
Underground mining exploitation causes deformations on the ground surface as a result of the filling of the resulting voids. In certain situations, apart from mild continuous deformations, discontinuous deformations may occur in the form of, e.g., steps ...
Leszek Szojda, Piotr Strzałkowski
doaj   +1 more source

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