Results 161 to 170 of about 11,456,586 (404)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Supply Chain Analysis of Raw Material Availability in Fast Food Industry of Mcdonald's Malang [PDF]

open access: yes, 2018
This research is important to understand how supply chain management, especially related to the supply of raw materials in the food and beverage industry, specifically in International franchising companies.
Anggawinata, F. (Felicia)
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Structure Unity and Practical Use of Natural and Synthetic Carbonic Materials

open access: yesХімія, фізика та технологія поверхні, 2010
It has been shown the unity of composition, molecular and supermolecular structure of shungite concentrate and silicon-carbon from rice hulls which provides their effective practical use in the same engineering processes as rubber fillers and sorbents.
S. V. Yefremova
doaj  

EPQ Model with Imperfect Quality Raw Material [PDF]

open access: yes, 2012
MSC 2010: 26A33, 33E12, 33C60, 44A20The classical economic production model (EPQ) has been extended in many directions to incorporate factors encountered in real-life situations.
Bitar, Mokarram   +2 more
core  

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

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